Abstract
Neurobehavioral impairments are frequently reported following treatment for childhood cancers, with cranial irradiation (CRT). This study investigated attention and information processing skills, predicting that these skills would be impaired due to the vulnerability of cerebral white matter in early childhood. Three treatment groups were studied: (i) CRT+chemotherapy (n = 35); (ii) chemotherapy alone (n = 19); (iii) healthy children (n = 35). All children were aged 9 to 16 years at time of assessment, with no pre-diagnosis history of neurologic, developmental, or psychiatric disorder. Children were administered a series of task measuring processing speed and sustained, selective, and shifting attention. For children treated with CRT + chemo, results identified residual deficits in processing speed for complex tasks, selective and shifting attention. In contrast, processing speed was intact for simple tasks, and there was no clear evidence of deterioration in performance over time, as might be expected in the presence of a sustained attention deficit. Children treated with chemotherapy alone demonstrated generally intact attentional skills. However, this group did record an increasing number of attentional lapses over time on t...Continue Reading
Citations
May 22, 2013·Neural Plasticity·Shaefali P RodgersJ Leigh Leasure
Jun 6, 2012·International Journal of Speech-language Pathology·Fiona M LewisBruce E Murdoch
Dec 25, 2015·Pediatric Blood & Cancer·Robert D AnnettSean Phipps
Oct 15, 2011·Journal of Hematology & Oncology·Christina HalseyBrenda Gibson
Dec 25, 2013·Journal of Psychosocial Oncology·Rebecca H FosterMarilyn Stern
Jan 13, 2012·PloS One·Vivian Capilla-GonzalezJose Manuel Garcia-Verdugo
Oct 23, 2010·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Kristina K HardyMelanie J Bonner
Oct 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory T ArmstrongLeslie L Robison
Oct 17, 2008·Developmental Disabilities Research Reviews·Celiane Rey-Casserly, Mary Ellen Meadows
Nov 10, 2017·Neuro-oncology·Iman SahnouneM Waleed Gaber
May 5, 2009·Journal of Neurosurgery. Pediatrics·Robert E Elliott, Jeffrey H Wisoff
Apr 3, 2009·Journal of Neurosurgery. Pediatrics·Robert E ElliottJeffrey H Wisoff
Jan 2, 2010·Journal of Neurosurgery. Pediatrics·Robert E ElliottJeffrey H Wisoff
Jun 18, 2011·Cancer Nursing·Maria GeraliHelen Vasilatou-Kosmidis
Oct 2, 2008·Acta Paediatrica·G Elisabeth LofstadTrond H Diseth
Jul 12, 2005·Pediatric Blood & Cancer·Catherine BauldC A Olsson
Apr 7, 2010·Neurosurgical Focus·Robert E ElliottJeffrey H Wisoff
Aug 7, 2007·Neuropsychological Rehabilitation·C BenjaminM Nash
Jul 9, 2008·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Eli VakilYoram Greenstein
Mar 9, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Leandra DesjardinsDiane Fairclough
Sep 1, 2014·Journal of Neuro-oncology·Evangelos DrimtziasIan Simmons
Dec 31, 2020·Journal of Pediatric Psychology·Leandra DesjardinsMaru Barrera