Impairments of Motor Function While Multitasking in HIV

Frontiers in Human Neuroscience
Sharif I KronemerCherie L Marvel

Abstract

Human immunodeficiency virus (HIV) became a treatable illness with the introduction of combination antiretroviral therapy (CART). As a result, patients with regular access to CART are expected to live decades with HIV. Long-term HIV infection presents unique challenges, including neurocognitive impairments defined by three major stages of HIV-associated neurocognitive disorders (HAND). The current investigation aimed to study cognitive and motor impairments in HIV using a novel multitasking paradigm. Unlike current standard measures of cognitive and motor performance in HIV, multitasking increases real-world validity by mimicking the dual motor and cognitive demands that are part of daily professional and personal settings (e.g., driving, typing and writing). Moreover, multitask assessments can unmask compensatory mechanisms, normally used under single task conditions, to maintain performance. This investigation revealed that HIV+ participants were impaired on the motor component of the multitask, while cognitive performance was spared. A patient-specific positive interaction between motor performance and working memory recall was driven by poor HIV+ multitaskers. Surprisingly, HAND stage did not correspond with multitask perfo...Continue Reading

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Citations

Oct 27, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jessica L MontoyaDavid J Moore
May 21, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Raha M DastgheybNorman J Haughey
Oct 7, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jessica Robinson-PappSusan Morgello
Oct 31, 2020·The Cerebellum·Owen P MorganCherie L Marvel

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