Impairments of movement kinematics in patients with Huntington's disease: a comparison with and without a concurrent task

Movement Disorders : Official Journal of the Movement Disorder Society
N GeorgiouEdmond Chiu

Abstract

This study aimed to quantify the efficiency and smoothness of voluntary movement in Huntington's disease (HD) by the use of a graphics tablet that permits analysis of movements profiles. In particular, we aimed to ascertain whether a concurrent task (digit span) would affect the kinematics of goal-directed movements. Twelve patients with HD and their matched controls performed 12 vertical zig-zag movements, with both left and right hands (with and without the concurrent task), to large or small circular targets over long or short extents. The concurrent task was associated with shorter movement times and reduced right-hand superiority. Patients with HD were overall slower, especially, with long strokes, and had similar peak velocities for both small and large targets, so that controls could better accommodate differences in target size. Patients with HD spent more time decelerating, especially with small targets, whereas controls allocated more nearly equal proportions of time to the acceleration and deceleration phases of movement, especially with large targets. Short strokes were generally less force inefficient than were long strokes, especially so for either hand in either group in the absence of the concurrent task, and fo...Continue Reading

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Citations

Mar 26, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·N GeorgiouJ G Phillips
Jun 8, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·D Joel
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Belinda BilneyNellie Georgiou-Karistianis
Jul 6, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A CurràA Berardelli
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Mar 23, 2005·Brain and Cognition·Claudine BouletFrancois Richer
Nov 6, 2014·Journal of Neurology·Eleftheria VaportzisJulie C Stout
Nov 6, 2007·Behavioural Brain Research·Martin LemayPaul Lesperance
Mar 17, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Jeroen P P van VugtRaymund A C Roos
Jun 21, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Robert JechJan Roth
Jan 13, 2019·Annals of Neurology·Malvindar K Singh-BainsRichard L M Faull
Apr 27, 2005·Annals of Neurology·Meir PlotnikJeffrey M Hausdorff
Jun 17, 2005·Brain : a Journal of Neurology·Tao Wu, Mark Hallett
Aug 15, 2020·Annals of Clinical and Translational Neurology·Johnny LoTravis M Cruickshank
Jun 2, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Clare M Eddy, Jennifer L Cook
Jun 4, 2013·Neuroscience and Biobehavioral Reviews·April L PhilpottNellie Georgiou-Karistianis

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