Impairments of prepulse inhibition of the startle response in abstinent alcoholic male patients

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Marta MarínGabriel Rubio

Abstract

Prepulse inhibition (PPI) of the startle reflex, which refers to the ability of innocuous sensory events to reduce the startle reflex, has been described as an operational measure of sensorimotor gating that is reduced in several neuropsychiatric disorders, such as schizophrenia, but experience is lacking in addictions and alcoholism. The aim of this study was to examine the existence of impairments in the startle response and PPI in abstinent alcoholic men. Testing for PPI was conducted on 60 abstinent alcoholic men aged 18-65 years (mean 46.37) who met DSM-IV criteria for alcohol dependence and had been abstinent for more than a month at the time of testing. The comparison group were compared with 37 sex- age- and education-matched controls without alcohol dependence. Magnitudes of the startle reflex were lower in patients than in controls. The differences were statistically significant (P < 0.05) in trials with prepulses presented 30 and 120 ms before the onset of the startle stimulus. There was also a statistically significant (P < 0.05) reduced percentage of PPI when the prepulse was presented 30 ms before the startle stimulus. These data suggest that sensory information processing mechanisms could be damaged in abstinent ...Continue Reading

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Citations

Nov 27, 2015·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Trina M Norden-KrichmarCindy L Ehlers
Mar 5, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Marta MarinGabriel Rubio
May 8, 2016·Alcoholism, Clinical and Experimental Research·Tracy R ButlerJeffrey L Weiner

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