PMID: 1453778Mar 1, 1992Paper

Impedance changes during the compound nerve action potential: implications for impedance imaging of neuronal depolarisation in the brain

Medical & Biological Engineering & Computing
D S Holder

Abstract

Impedance changes were measured during the compound action potential (CAP) in isolated crab nerves with 50 kHz or direct applied current (DC), to suggest an optimal frequency for the imaging of neuronal depolarisation by electrical impedance tomography (EIT). With DC, a predominant apparent impedance decrease of 0.2-0.7 per cent of the resting baseline was observed, which had a time course similar to that of the action potential. Control recordings suggested that these changes could not be attributed to technical errors resulting from the measurement method. A component in some measurements was attributable to effects of the measuring current on the latency of the CAP, but the mechanism underlying the remainder of the changes was unclear. No changes greater than +/- 0.005 per cent were seen with measurement at 50 kHz. This suggests that research into noninvasive rapid imaging of nervous activity in the brain with EIT would be more profitably performed with measurements at frequencies lower than the 50 kHz currently used for safety reasons.

References

Mar 5, 1990·Behavioural Brain Research·W G Webster
Aug 1, 1989·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·D S Holder
Jan 1, 1988·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·D S Holder, A R Gardner-Medwin
Jan 1, 1987·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·B H Brown, A D Seagar
May 1, 1985·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·B H BrownA D Seagar
Jul 1, 1968·Journal of Neurophysiology·K A Klivington, R Galambos
Jul 16, 1990·Physical Review Letters·J G Berryman, R V Kohn
Jun 1, 1955·Journal of Cellular Physiology·W H FREYGANG, W M LANDAU
Oct 1, 1956·The American Journal of Physiology·S OCHS, A VAN HARREVELD
Jul 1, 1962·The Journal of General Physiology·F J JULIAND E GOLDMAN
Mar 1, 1951·The Journal of Physiology·R D KEYNES, P R LEWIS
Jul 31, 1947·The Journal of Physiology·A L Hodgkin
May 20, 1939·The Journal of General Physiology·K S Cole, H J Curtis

❮ Previous
Next ❯

Citations

Jan 1, 1992·Brain Topography·D S Holder
Jun 1, 2017·Journal of Physiology, Paris·Alexandre FouchardOlivier David
Jun 27, 2019·Journal of Neural Engineering·Ilya TarotinDavid Holder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.