Imperatorin reduces the inflammatory response of atherosclerosis by regulating MAPKs signaling pathway in vivo and in vitro.

International Immunopharmacology
Wenqi LiWeifeng Li

Abstract

Inflammation plays an important role in the process of atherosclerosis (AS). Inhibition of inflammation is an effective way to prevent AS. Imperatorin (IMP) is a kind of furan coumarin with various activities. In this study, the anti-inflammatory effect of IMP was explored in oxidized low-density lipoprotein (ox-LDL)-induced VSMCs and high fat diet (HFD)-induced ApoE-/- mice. The results showed that IMP attenuated the elevation of TNF-α, IL-6, MCP-1 and NO induced by ox-LDL in supernatant of VSMCs. IMP has normalized the levels of serum lipids (TC, TG, LDL-C and HDL-C) and attenuated inflammatory cytokines in serum. IMP also improved pathological changes and lipid accumulation in aorta. Matrix metalloproteinase-2 (MMP-2) expression in aorta was down-regulated by IMP. IMP could inhibit the phosphorylation of MAPKs pathway in the aorta and VSMCs, resulting in a significant decrease in the contents of p-ERK 1/2, p-JNK and p-P38. Overall, IMP could exert anti-inflammatory effects in vivo and in vitro to interfere with AS.

References

May 26, 2001·The Journal of Clinical Investigation·M I CybulskyD S Milstone
Jan 16, 2002·Current Opinion in Immunology·Leanne PeiserSiamon Gordon
Jul 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Johannes Hulthe, Björn Fagerberg
Apr 17, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Karen S Meir, Eran Leitersdorf
Jul 29, 2005·The New England Journal of Medicine·Jaime García de Tena
Feb 25, 2006·The Canadian Journal of Cardiology·Thierry CharronBradley H Strauss
Oct 22, 2008·Oncogene·D N Dhanasekaran, E P Reddy
Jan 1, 2008·Drug Discovery Today. Therapeutic Strategies·Xiao-Feng YangHong Wang
Nov 11, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Sang Hun ShinJae Ho Kim
Jan 26, 2011·Molecular Genetics and Metabolism·Sunaina Gautam, Monisha Banerjee
Feb 23, 2011·Antioxidants & Redox Signaling·Jingjun LuJawahar L Mehta
Mar 13, 2012·Cardiovascular Research·Delphine Gomez, Gary K Owens
Apr 24, 2012·Current Topics in Medicinal Chemistry·Konstantinos ToutouzasChristodoulos Stefanadis
Sep 19, 2012·The Canadian Journal of Cardiology·Brian W WongBruce M McManus
Nov 6, 2012·Cellular and Molecular Life Sciences : CMLS·Suowen XuPeiqing Liu
Jun 21, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiao-Hua YuChao-Ke Tang
Feb 8, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Marie FiskJoseph Cheriyan
Jan 17, 2015·Circulation Research·Kevin M PatelDaniel J Rader
Apr 14, 2015·Seminars in Immunology·Joana Viola, Oliver Soehnlein
May 26, 2015·Cytokine & Growth Factor Reviews·Dipak P Ramji, Thomas S Davies
Oct 1, 2015·European Heart Journal·Konstantinos ToutouzasDimitris Tousoulis
Feb 29, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Alexander N Orekhov, Ekaterina A Ivanova
Jul 21, 2016·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Rayana Ariane Pereira MacielAndréa Emilia Marques Stinghen
Aug 6, 2016·BioMed Research International·Yuri V BobryshevAlexander N Orekhov
Jan 17, 2017·International Journal of Cardiology·Vincenzo MarzollaMassimiliano Caprio
May 10, 2017·European Journal of Pharmacology·Besa Emini VeseliGuido R Y De Meyer
Jul 13, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Min FengXiao-Li Ye
Nov 18, 2017·Endocrinología, Diabetes Y Nutrición·Miguel Ruiz-Canela, Miguel A Martínez-González
Aug 2, 2018·Journal of Hematology & Oncology·Pu FangHong Wang
Oct 18, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M I NasserPing Zhu
Jan 5, 2020·Bioscience, Biotechnology, and Biochemistry·Zhemin XianGuanghai Yan

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