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Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multi-drug resistance

bioRxiv

Dec 19, 2014

Stefany Moreno-GamezPleuni Simone Pennings

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Abstract

Infections with rapidly evolving pathogens are often treated using combinations of drugs with different mechanisms of action. One of the major goals of combination therapy is to reduce the risk of drug resistance emerging during a patient's treatment. While this strategy generally has s...read more

Mentioned in this Paper

Resistance to Infection
Parasites
Drug Combinations
Microbicides
Resistance Process
Virus
Anatomical Compartments
Public Health Domain
Combination Drug Therapy
Microbial
25
1
103
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  • Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multi-drug resistance

    bioRxiv

    Dec 19, 2014

    Stefany Moreno-GamezPleuni Simone Pennings

    PMID: 990013003

    DOI: 10.1101/013003

    Abstract

    Infections with rapidly evolving pathogens are often treated using combinations of drugs with different mechanisms of action. One of the major goals of combination therapy is to reduce the risk of drug resistance emerging during a patient's treatment. While this strategy generally has s...read more

    Mentioned in this Paper

    Resistance to Infection
    Parasites
    Drug Combinations
    Microbicides
    Resistance Process
    25
    1
    103

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