Implant-Assisted Intrathecal Magnetic Drug Targeting to Aid in Therapeutic Nanoparticle Localization for Potential Treatment of Central Nervous System Disorders

Journal of Biomedical Nanotechnology
Eric LueshenAndreas Linninger

Abstract

There is an ongoing struggle to develop efficient drug delivery and targeting methods within the central nervous system. One technique known as intrathecal drug delivery, involves direct drug infusion into the spinal canal and has become standard practice for treating many central nervous system diseases due to reduced systemic toxicity from the drug bypassing the blood-brain barrier. Although intrathecal drug delivery boasts the advantage of reduced systemic toxicity compared to oral and intravenous drug delivery techniques, current intrathecal delivery protocols lack a means of sufficient drug targeting at specific locations of interest within the central nervous system. We previously proposed the method of intrathecal magnetic drug targeting in order to overcome the limited targeting capabilities of standard intrathecal drug delivery protocols, while simultaneously reducing the systemic toxicity as well as the amount of drug required to produce a therapeutic effect. Building off of our previous work, this paper presents the concept of implant-assisted intrathecal magnetic drug targeting. Ferritic stainless steel implants were incorporated within the subarachnoid space of our in vitro human spine model, and the targeting magn...Continue Reading

Citations

Aug 15, 2015·Biochemical and Biophysical Research Communications·Rainer TietzeChristoph Alexiou
Aug 4, 2015·Neurosurgical Focus·Matthew K TobinAnkit I Mehta
Sep 16, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Seyed Mohsen AberoumandiSoodabeh Davaran
Dec 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Federico D'AgataCaterina Guiot
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Aug 4, 2015·Journal of Neuro-oncology·Ankit I MehtaHerbert H Engelhard
Sep 7, 2019·Nanotechnology·Kai WuJian-Ping Wang
Jul 8, 2016·Annals of Biomedical Engineering·K TangenA A Linninger
Jul 1, 2017·Global Spine Journal·Gordon D SkeochAnkit I Mehta
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Mar 25, 2017·Nanomedicine·Indu VenugopalAndreas Linninger
Nov 19, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ayankola O AyansijiMeenesh R Singh
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