Implant-associated gene expression in the jaw bone of smokers and nonsmokers: A human study using quantitative qPCR

Clinical Oral Implants Research
Shariel SayardoustPeter Thomsen

Abstract

This study aimed to compare the molecular events in implant-adherent cells and in peri-implant bone during the osseointegration of machined and oxidized titanium implants in smokers and nonsmokers. Twenty-four smokers and 24 nonsmokers each received machined and anodically oxidized mini-implants. The mini-implants and the surrounding bone were retrieved after 1, 7, and 28 days, for gene expression analysis of selected factors using quantitative polymerase chain reaction (qPCR). Differences between machined and oxidized implants were more evident in the implant-adherent cells than the peri-implant bone. The machined implants revealed higher expression of proinflammatory cytokines, interleukin-8 (IL-8) (in nonsmokers), and tumor necrosis factor-alpha (in nonsmokers and smokers), compared with the oxidized implants. Conversely, the expression of bone formation genes, alkaline phosphatase and osteocalcin, was generally higher at the oxidized implants. In smokers, the temporal pattern revealed the delayed and initial inhibition of osteoblastic and osteoclastic gene expression, respectively, mainly at the machined implants. In contrast, oxidized implants revealed higher expression of bone remodeling, cathepsin K (CatK) and calcitonin...Continue Reading

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Citations

Mar 1, 2019·Clinical Implant Dentistry and Related Research·Franz Josef StraussReinhard Gruber
Sep 20, 2019·Calcified Tissue International·Furqan A ShahAnders Palmquist
Feb 25, 2021·ACS Biomaterials Science & Engineering·Sutton E WheelisDanieli C Rodrigues
Nov 18, 2018·Acta Biomaterialia·Furqan A ShahAnders Palmquist

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