Abstract
Bony fixation of cementless orthopaedic implants is not always achieved, particularly in challenging scenarios such as revision surgery, trauma, and tumor reconstruction. An adjunct therapy for improving porous implant fixation could improve the reliability and durability of these reconstructive procedures. In this study, we asked whether there is a positive and dose-dependent effect of the local release of the bisphosphonate alendronate from (1) alendronate/hydroxyapatite (HA) porous-coated titanium implants compared with bare metal porous controls; and (2) alendronate/HA on porous-coated titanium implants compared with HA-coated porous controls with respect to extent of bone ingrowth, bone apposition, and periimplant bone formation in a canine model? Three-dimensional printed porous-coated cylindrical implants coated with three different doses (0.02, 0.06, and 0.18 mg/cm(2)) of alendronate were inserted bilaterally in the intramedullary canal of the proximal femora of 15 adult mongrel dogs (age range, 3-9 years; mean, 5 years) weighing between 36 kg and 60 kg (mean, 43 kg). In each dog, an implant coated with HA and one of three different doses of alendronate was inserted on one side while the contralateral femur had a bare m...Continue Reading
References
May 3, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D R SumnerJ O Galante
Jun 19, 2002·Biomaterials·M YoshinariM Shimono
Dec 5, 2003·The Journal of Bone and Joint Surgery. British Volume·S A HackingJ D Bobyn
Jan 27, 2004·Biomaterials·P TengvallP Aspenberg
Jan 25, 2005·Bone·B PeterO Gauthier
Feb 3, 2005·The Journal of Bone and Joint Surgery. American Volume·Mohit BhandariThomas A Einhorn
Oct 29, 2005·Journal of Biomedical Materials Research. Part a·Bastian PeterDominique P Pioletti
Dec 7, 2005·Clinical Orthopaedics and Related Research·Michael TanzerJ Dennis Bobyn
Dec 1, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Allen E GoodshipMelanie J Coathup
Feb 1, 2008·Acta Orthopaedica·Maria Hilding, Per Aspenberg
May 3, 2008·The Journal of Bone and Joint Surgery. American Volume·Donald S GarbuzClive P Duncan
Aug 30, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Thomas JakobsenKjeld Søballe
Aug 30, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mohammad ArabmotlaghMichael Rauschmann
Jan 13, 2009·Biomaterials·Ying GaoJing Hu
Feb 3, 2009·The Journal of Bone and Joint Surgery. American Volume·Gerald FriedlReinhard Windhager
Jul 3, 2009·Hormones : International Journal of Endocrinology and Metabolism·Peter D Papapetrou
Nov 26, 2009·The Journal of Bone and Joint Surgery. American Volume·J Dennis BobynMichael Tanzer
Sep 3, 2010·Clinical Orthopaedics and Related Research·Kimberly McKenzieMichael Tanzer
Sep 8, 2011·Acta Orthopaedica·Marianne T VestermarkJorgen Baas
Dec 8, 2011·BMJ : British Medical Journal·Daniel Prieto-AlhambraNigel K Arden
May 11, 2012·The New England Journal of Medicine·Marcea WhitakerGeorge Benson
Feb 15, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lydia GedmintasSeoyoung C Kim
Jul 3, 2013·Clinical Orthopaedics and Related Research·J Dennis BobynMichael Tanzer
Apr 29, 2014·The Journal of Arthroplasty·Ivan DzajaJames L Howard
Jul 6, 2014·Journal of Materials Science. Materials in Medicine·Kenta UemuraMasataka Sakane
Feb 14, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Ulrike KettenbergerDominique P Pioletti
Jun 5, 2015·The Orthopedic Clinics of North America·Neil P ShethWayne G Paprosky
Citations
Dec 14, 2016·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Shariq NajeebShazia Akbar Ansari
Mar 21, 2017·Acta Biomaterialia·J-L WangN Birbilis
Sep 7, 2018·Clinical Oral Investigations·Arash KhojastehPantea Nazeman
Nov 7, 2019·Advanced Healthcare Materials·Yutao CuiJianxun Ding
Jan 24, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hannah SpeceSteven M Kurtz
Nov 2, 2019·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Theofilos S KarachaliosGeorge A Komnos