Implant-delivered Alendronate Causes a Dose-dependent Response on Net Bone Formation Around Porous Titanium Implants in Canines

Clinical Orthopaedics and Related Research
Jenny Ann PuraM Tanzer

Abstract

Bony fixation of cementless orthopaedic implants is not always achieved, particularly in challenging scenarios such as revision surgery, trauma, and tumor reconstruction. An adjunct therapy for improving porous implant fixation could improve the reliability and durability of these reconstructive procedures. In this study, we asked whether there is a positive and dose-dependent effect of the local release of the bisphosphonate alendronate from (1) alendronate/hydroxyapatite (HA) porous-coated titanium implants compared with bare metal porous controls; and (2) alendronate/HA on porous-coated titanium implants compared with HA-coated porous controls with respect to extent of bone ingrowth, bone apposition, and periimplant bone formation in a canine model? Three-dimensional printed porous-coated cylindrical implants coated with three different doses (0.02, 0.06, and 0.18 mg/cm(2)) of alendronate were inserted bilaterally in the intramedullary canal of the proximal femora of 15 adult mongrel dogs (age range, 3-9 years; mean, 5 years) weighing between 36 kg and 60 kg (mean, 43 kg). In each dog, an implant coated with HA and one of three different doses of alendronate was inserted on one side while the contralateral femur had a bare m...Continue Reading

References

May 3, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D R SumnerJ O Galante
Dec 5, 2003·The Journal of Bone and Joint Surgery. British Volume·S A HackingJ D Bobyn
Feb 3, 2005·The Journal of Bone and Joint Surgery. American Volume·Mohit BhandariThomas A Einhorn
Oct 29, 2005·Journal of Biomedical Materials Research. Part a·Bastian PeterDominique P Pioletti
Dec 7, 2005·Clinical Orthopaedics and Related Research·Michael TanzerJ Dennis Bobyn
Dec 1, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Allen E GoodshipMelanie J Coathup
May 3, 2008·The Journal of Bone and Joint Surgery. American Volume·Donald S GarbuzClive P Duncan
Aug 30, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Thomas JakobsenKjeld Søballe
Aug 30, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mohammad ArabmotlaghMichael Rauschmann
Feb 3, 2009·The Journal of Bone and Joint Surgery. American Volume·Gerald FriedlReinhard Windhager
Jul 3, 2009·Hormones : International Journal of Endocrinology and Metabolism·Peter D Papapetrou
Nov 26, 2009·The Journal of Bone and Joint Surgery. American Volume·J Dennis BobynMichael Tanzer
Sep 3, 2010·Clinical Orthopaedics and Related Research·Kimberly McKenzieMichael Tanzer
Sep 8, 2011·Acta Orthopaedica·Marianne T VestermarkJorgen Baas
May 11, 2012·The New England Journal of Medicine·Marcea WhitakerGeorge Benson
Feb 15, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lydia GedmintasSeoyoung C Kim
Jul 3, 2013·Clinical Orthopaedics and Related Research·J Dennis BobynMichael Tanzer
Apr 29, 2014·The Journal of Arthroplasty·Ivan DzajaJames L Howard
Jul 6, 2014·Journal of Materials Science. Materials in Medicine·Kenta UemuraMasataka Sakane
Feb 14, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Ulrike KettenbergerDominique P Pioletti
Jun 5, 2015·The Orthopedic Clinics of North America·Neil P ShethWayne G Paprosky

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Citations

Dec 14, 2016·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Shariq NajeebShazia Akbar Ansari
Nov 7, 2019·Advanced Healthcare Materials·Yutao CuiJianxun Ding
Jan 24, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hannah SpeceSteven M Kurtz
Nov 2, 2019·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Theofilos S KarachaliosGeorge A Komnos

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