Implantable cardioverter-defibrillator therapy in device recipients who survived a cardiac arrest associated with a reversible cause

Journal of Cardiovascular Electrophysiology
Aman GuptaSamir Saba

Abstract

Guideline recommendations for implantable cardioverter-defibrillators (ICD) for secondary prevention of sudden cardiac arrest (SCA) have excluded patients with reversible causes. We previously demonstrated mortality benefit with the ICD in survivors of SCA associated with reversible causes other than myocardial infarction (MI) or ischemia treated with coronary revascularization. In the current study, we examined the incidence of ICD therapy in patients with SCA related to reversible causes. Data were collected for all patients over the age of 18 years who had survived to hospital discharge after SCA between 2002 and 2012. ICD recipients with reversible causes were divided into 2 groups based on their reversible etiology of SCA: MI + ICD (n = 132) and non-MI + ICD (n = 75). Delivered ICD therapy was examined. Over a follow-up period of 3.8 ± 3.1 years, more patients without MI/ischemia who received an ICD experienced appropriate (adjusted HR, 3.96; 95% CI, 1.32-11.84) but not inappropriate (adjusted HR, 0.65; 95% CI, 0.14-2.97) ICD therapy compared with patients without MI/ischemia. The proportion of patients receiving appropriate (P = 0.012) but not inappropriate (P = 0.80) ICD therapy was also higher in the non-MI + ICD compar...Continue Reading

References

Dec 31, 1997·The New England Journal of Medicine·UNKNOWN Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators
Sep 19, 2000·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·P Della Bella
Nov 13, 2001·Journal of the American College of Cardiology·D G WyseUNKNOWN AVID Investigators
Apr 18, 2006·The American Journal of Cardiology·Joseph J GermanoMark E Josephson
Sep 17, 2013·Journal of the American College of Cardiology·Frederick A MasoudiJohn S Rumsfeld
Jun 16, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ryan T Borne, Paul D Varosy
Feb 2, 2018·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Mar 17, 2018·Circulation. Arrhythmia and Electrophysiology·Adetola LadejobiSamir Saba

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