Implantable cardioverter-defibrillators in heart failure patients with reduced ejection fraction and diabetes

European Journal of Heart Failure
Abhinav SharmaGillian D Sanders

Abstract

There is limited information on the outcomes after primary prevention implantable cardioverter-defibrillator (ICD) implantation in patients with heart failure (HF) and diabetes. This analysis evaluates the effectiveness of a strategy of ICD plus medical therapy vs. medical therapy alone among patients with HF and diabetes. A patient-level combined-analysis was conducted from a combined dataset that included four primary prevention ICD trials of patients with HF or severely reduced ejection fractions: Multicenter Automatic Defibrillator Implantation Trial I (MADIT I), MADIT II, Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE), and Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). In total, 3359 patients were included in the analysis. The primary outcome of interest was all-cause death. Compared with patients without diabetes (n = 2363), patients with diabetes (n = 996) were older and had a higher burden of cardiovascular risk factors. During a median follow-up of 2.6 years, 437 patients without diabetes died (178 with ICD vs. 259 without) and 280 patients with diabetes died (128 with ICD vs. 152 without). ICDs were associated with a reduced risk of all-cause mortality among patients without dia...Continue Reading

References

Mar 22, 2002·The New England Journal of Medicine·Arthur J MossUNKNOWN Multicenter Automatic Defibrillator Implantation Trial II Investigators
May 21, 2004·The New England Journal of Medicine·Alan KadishUNKNOWN Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) Investigators
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Nov 16, 2010·The New England Journal of Medicine·Faiez ZannadUNKNOWN EMPHASIS-HF Study Group
Jul 20, 2014·Circulation. Arrhythmia and Electrophysiology·Paul L HessSana M Al-Khatib
Sep 2, 2014·The New England Journal of Medicine·John J V McMurrayUNKNOWN PARADIGM-HF Investigators and Committees
Sep 18, 2015·The New England Journal of Medicine·Bernard ZinmanUNKNOWN EMPA-REG OUTCOME Investigators
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Aug 30, 2016·The New England Journal of Medicine·Lars KøberUNKNOWN DANISH Investigators
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Mar 17, 2017·European Journal of Heart Failure·Kavita Sharma, James C Fang
Jul 6, 2017·The New England Journal of Medicine·Li ShenJohn J V McMurray

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Citations

Aug 16, 2019·European Journal of Heart Failure·Andrew J S Coats
Jan 29, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Rasmus RørthJohn J V McMurray
Jul 20, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Rasmus RørthSøren L Kristensen
Jan 31, 2020·ESC Heart Failure·Daniela TomasoniMarco Metra
Nov 27, 2019·European Journal of Preventive Cardiology·Marc FerriniVictor Aboyans
Dec 6, 2020·ESC Heart Failure·Daniela TomasoniMarco Metra
May 27, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Wilfried MullensChristophe Leclercq
Aug 2, 2021·JACC. Clinical Electrophysiology·Ramkumar V VenkateswaranChristine M Albert
Aug 21, 2020·JACC. Clinical Electrophysiology·Laura WhiteMahmood Ahmad

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