Implantable neurotechnologies: a review of integrated circuit neural amplifiers

Medical & Biological Engineering & Computing
Kian Ann NgNitish V Thakor

Abstract

Neural signal recording is critical in modern day neuroscience research and emerging neural prosthesis programs. Neural recording requires the use of precise, low-noise amplifier systems to acquire and condition the weak neural signals that are transduced through electrode interfaces. Neural amplifiers and amplifier-based systems are available commercially or can be designed in-house and fabricated using integrated circuit (IC) technologies, resulting in very large-scale integration or application-specific integrated circuit solutions. IC-based neural amplifiers are now used to acquire untethered/portable neural recordings, as they meet the requirements of a miniaturized form factor, light weight and low power consumption. Furthermore, such miniaturized and low-power IC neural amplifiers are now being used in emerging implantable neural prosthesis technologies. This review focuses on neural amplifier-based devices and is presented in two interrelated parts. First, neural signal recording is reviewed, and practical challenges are highlighted. Current amplifier designs with increased functionality and performance and without penalties in chip size and power are featured. Second, applications of IC-based neural amplifiers in basic...Continue Reading

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Citations

Jan 13, 2016·Medical & Biological Engineering & Computing·Elliot GreenwaldNitish V Thakor
Jan 13, 2016·Medical & Biological Engineering & Computing·Sudip Nag, Nitish V Thakor
Jan 13, 2016·Medical & Biological Engineering & Computing·Anoop C Patil, Nitish V Thakor
Mar 1, 2016·Medical & Biological Engineering & Computing·Elliot GreenwaldNitish V Thakor
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Jan 28, 2021·Micromachines·Csaba ForroGabriella Panuccio
Feb 20, 2021·Journal of Neural Engineering·Le Cai, Philipp Gutruf

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