Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterations

The International Journal of Artificial Organs
Line VikingssonJosé L Gómez Ribelles

Abstract

Articular cartilage has limited repair capacity. Two different implant devices for articular cartilage regeneration were tested in vivo in a sheep model to evaluate the effect of subchondral bone anchoring for tissue repair. The implants were placed with press-fit technique in a cartilage defect after microfracture surgery in the femoral condyle of the knee joint of the sheep and histologic and mechanical evaluation was done 4.5 months later. The first group consisted of a biodegradable polycaprolactone (PCL) scaffold with double porosity. The second test group consisted of a PCL scaffold attached to a poly(L-lactic acid) (PLLA) pin anchored to the subchondral bone. For both groups most of the defects (75%) showed an articular surface that was completely or almost completely repaired with a neotissue. Nevertheless, the surface had a rougher appearance than controls and the repair tissue was immature. In the trials with solely scaffold implantation, severe subchondral bone alterations were seen with many large nodular formations. These alterations were ameliorated when implanting the scaffold with a subchondral bone anchoring pin. The results show that tissue repair is improved by implanting a PCL scaffold compared to solely mic...Continue Reading

References

Jan 1, 1984·Journal of Biomechanics·V C MowW M Lai
May 14, 1993·Science·R Langer, J P Vacanti
Nov 9, 2000·Biomaterials·D W Hutmacher
May 4, 2001·Journal of Biomaterials Science. Polymer Edition·D W Hutmacher
Oct 18, 2001·Clinical Orthopaedics and Related Research·J R SteadmanJ J Rodrigo
Apr 26, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·Matthias ChiquetMartin Flück
May 2, 2003·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·J Richard SteadmanWilliam G Rodkey
Feb 17, 2005·Journal of Biomechanics·Georg N DudaHermann Bail
Jul 9, 2005·Nature Materials·Scott J Hollister
Jan 12, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Erhan BasadJürgen Steinmeyer
Jan 23, 2010·The American Journal of Sports Medicine·Santos Martinez-DiazJoan Carles Monllau
Feb 5, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Andreas H GomollElizaveta Kon
Jan 23, 2014·Journal of the Mechanical Behavior of Biomedical Materials·L VikingssonJ L Gómez Ribelles
Feb 4, 2014·Archives of Orthopaedic and Trauma Surgery·Verena M A QuarchKarl-Heinz Frosch
Mar 31, 2015·Journal of Biomechanics·L VikingssonJ L Gómez Ribelles
Apr 29, 2015·Journal of the Mechanical Behavior of Biomedical Materials·L VikingssonJ L Gómez Ribelles
May 9, 2015·The International Journal of Artificial Organs·María Sancho-TelloCarmen Carda
Dec 1, 2014·Journal of Experimental Orthopaedics·Elizaveta KonMaurilio Marcacci

❮ Previous
Next ❯

Citations

Sep 15, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Javier Zurriaga CardaJosé L Gómez Ribelles
Nov 30, 2018·The International Journal of Artificial Organs·Mina Hajihasani BioukiMorteza Daliri Joupari
Oct 13, 2017·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·M DrobnicG Filardo
Jun 3, 2017·The International Journal of Artificial Organs·María Sancho-TelloCarmen Carda
Mar 21, 2017·The International Journal of Artificial Organs·Nada Z AlarakeMarkus Pietzsch

❮ Previous
Next ❯

Datasets Mentioned

BETA
EP201131625

Methods Mentioned

BETA
dissection

Software Mentioned

SPSS Statistics
Excel
Image proPlus

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association
David C FlaniganRobert A Siston
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Yusup AahmatZhenbin Wang
Technology and Health Care : Official Journal of the European Society for Engineering and Medicine
R M PilliarM Hurtig
© 2022 Meta ULC. All rights reserved