Implantation of Neural Probes in the Brain Elicits Oxidative Stress

Frontiers in Bioengineering and Biotechnology
Evon S EreifejJeffrey R Capadona

Abstract

Clinical implantation of intracortical microelectrodes has been hindered, at least in part, by the perpetual inflammatory response occurring after device implantation. The neuroinflammatory response observed after device implantation has been correlated to oxidative stress that occurs due to neurological injury and disease. However, there has yet to be a definitive link of oxidative stress to intracortical microelectrode implantation. Thus, the objective of this study is to give direct evidence of oxidative stress following intracortical microelectrode implantation. This study also aims to identify potential molecular targets to attenuate oxidative stress observed postimplantation. Here, we implanted adult rats with silicon non-functional microelectrode probes for 4 weeks and compared the oxidative stress response to no surgery controls through postmortem gene expression analysis and qualitative histological observation of oxidative stress markers. Gene expression analysis results at 4 weeks postimplantation indicated that EH domain-containing 2, prion protein gene (Prnp), and Stearoyl-Coenzyme A desaturase 1 (Scd1) were all significantly higher for animals implanted with intracortical microelectrode probes compared to no surge...Continue Reading

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Citations

May 15, 2018·Journal of Neural Engineering·Robert K ShepherdDavid A X Nayagam
Jun 5, 2019·Journal of Biomedical Materials Research. Part a·Hanna LiliomKatalin Schlett
Jun 18, 2019·Advanced Materials·Nikita ObidinCanan Dagdeviren
Oct 15, 2019·Advanced Materials·Florian FalleggerStéphanie P Lacour
Aug 2, 2018·Frontiers in Neuroscience·Youjoung KimEvon S Ereifej
May 28, 2020·Frontiers in Bioengineering and Biotechnology·Shreya MahajanEvon S Ereifej
Sep 27, 2019·Journal of Neural Engineering·Evon S EreifejPaul D Marasco
Aug 31, 2018·Frontiers in Bioengineering and Biotechnology·John K HermannJeffrey R Capadona
May 23, 2020·International Journal of Molecular Sciences·Rebecca M HaleyEvon S Ereifej
Apr 30, 2021·Frontiers in Cellular Neuroscience·Ouzéna Bouadi, Tuan Leng Tay
Mar 30, 2021·Journal of Neural Engineering·Cort H ThompsonErin K Purcell
May 25, 2021·Advanced Science·Eve McGlynnHadi Heidari

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Methods Mentioned

BETA
delamination
Laser Capture Microdissection
PCR
gene knock out

Software Mentioned

Leica
SDS

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