Implanted gold markers for position verification during irradiation of head-and-neck cancers: a feasibility study

International Journal of Radiation Oncology, Biology, Physics
Bram van AsselenChris H J Terhaard

Abstract

To assess the toxicity and reliability of the use of implanted gold markers for position verification during irradiation of head-and-neck cancer. Ten patients with localized head-and-neck tumors received two gold markers in the parapharyngeal region. The acute and late radiation-related toxicity were scored prospectively using the Common Toxicity Criteria. The patients were immobilized during irradiation using a five-point mask. The marker location was detected in portal images taken with an a-Si flat panel imager. The intermarker distance, as well as the interfraction motion of the markers, was determined for all patients. No acute major complications were observed. The acute toxicity grade was not greater than normally detected. The markers were visible in all images. On average, the projected intermarker distance varied 0.8 mm (1 standard deviation). A small time trend was observed in the intermarker distance for 3 patients. For these patients, at least one marker was located in the mucosa or pharyngeal constrictor muscle. Deeper-seated gold markers did not show a time trend in the intermarker distance. The random positioning uncertainty determined using the markers was on average 1.1 and 1.4 mm (1 SD) in the craniocaudal an...Continue Reading

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Citations

Feb 15, 2005·International Journal of Radiation Oncology, Biology, Physics·Eleftheria AstreinidouJan J W Lagendijk
May 9, 2012·International Journal of Radiation Oncology, Biology, Physics·Olga Hamming-VriezeCoenraad Robert Nico Rasch
May 12, 2009·International Journal of Radiation Oncology, Biology, Physics·Omar A ZeidanRafael R Manon
Apr 9, 2008·International Journal of Radiation Oncology, Biology, Physics·Heng LiAdam S Garden
May 2, 2008·Journal of Applied Clinical Medical Physics·James G MechalakosHoward I Amols
Apr 16, 2014·Advanced Healthcare Materials·Rasmus I JølckThomas L Andresen
May 20, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Victoria FischmanScharukh Jalisi

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