Implementation of a 5-Minute Magnetic Resonance Imaging Screening Protocol for Prostate Cancer in Men With Elevated Prostate-Specific Antigen Before Biopsy

Investigative Radiology
Jakob WeissSergios Gatidis

Abstract

The aims of this study were to establish a 5-minute magnetic resonance (MR) screening protocol for prostate cancer in men before biopsy and to evaluate effects on Prostate Imaging Reporting and Data System (PI-RADS) V2 scoring in comparison to a conventional, fully diagnostic multiparametric MR imaging (mpMRI) approach. Fifty-two patients with elevated prostate-specific antigen levels and without prior biopsy were prospectively included in this institutional review board-approved study. In all patients, an mpMRI protocol according to the PI-RADS recommendations was acquired on a 3 T MRI system. In addition, an accelerated diffusion-weighted imaging sequence was acquired using simultaneous multislice technique (DW-EPISMS). Two readers independently evaluated the images for the presence/absence of prostate cancer according to the PI-RADS criteria and for additional findings. In a first reading session, only the screening protocol consisting of axial T2-weighted and DW-EPISMS images was made available. In a subsequent reading session, the mpMRI protocol was assessed blinded to the results of the first reading, serving as reference standard. Both readers successfully established a final diagnosis according to the PI-RADS criteria i...Continue Reading

References

Sep 21, 2011·Radiology·Caroline M A HoeksJurgen J Fütterer
Mar 8, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Edward J AuerbachKâmil Uğurbil
Jun 25, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christiane K KuhlHeribert B Bieling
Sep 16, 2015·Current Opinion in Urology·Mrishta Brizmohun AppayyaShonit Punwani
Dec 17, 2016·Journal of Magnetic Resonance Imaging : JMRI·Li FengHersh Chandarana
Feb 16, 2017·Journal of Magnetic Resonance Imaging : JMRI·Jakob WeissMike Notohamiprodjo
Mar 21, 2017·European Urology·Marco MoschiniChristopher Parker
Apr 8, 2017·Clinical Radiology·D A WoodrumL A Mynderse
Apr 20, 2017·Investigative Radiology·Jana TaronMike Notohamiprodjo
Apr 26, 2017·Prostate Cancer and Prostatic Diseases·K J TayT J Polascik
Jun 1, 2017·Current Opinion in Urology·Adrian RhuddVeeru Kasivisvanathan
Jul 4, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jurgen J Fütterer

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Citations

Nov 6, 2018·Investigative Radiology·Julia MaiTobias Franiel
Mar 23, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Rodrigo CanellasDushyant V Sahani
Apr 5, 2019·Investigative Radiology·Val M RungeJohannes T Heverhagen
Jul 23, 2020·Nature Reviews. Urology·David Eldred-EvansHashim U Ahmed
Jan 30, 2019·European Radiology Experimental·Rossano GiromettiChiara Zuiani
Sep 20, 2020·Diagnostics·Samuel J GalganoSoroush Rais-Bahrami
Nov 3, 2020·Current Urology Reports·Neha Udayakumar, Kristin K Porter
Mar 2, 2021·European Journal of Radiology Open·Daniel StockerOlivio F Donati
Oct 21, 2020·European Journal of Radiology·Charlotte ChristopheRaphaële Renard-Penna
Aug 10, 2021·Insights Into Imaging·Andreas M HötkerOlivio F Donati

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