Implementation of a peroral endoscopic myotomy program.

Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
Pablo Miranda-GarcíaCecilio Santander Vaquero

Abstract

the aim of our study was to develop a peroral endoscopic myotomy (POEM) program in our Unit following a two-step sequence: training on animal models and supervision by an experienced endoscopist during the first human cases. a single endoscopist experienced in advanced endoscopy was trained in POEM. After observing POEM in referral centers, training was implemented on swine models (preclinical phase). Technical aspects and adverse events were prospectively recorded. A first subset of cases (group A) was compared to a second one (group B) to assess our progression. Finally, POEM was implemented in humans under the supervision of an experienced endoscopist (clinical phase). The outcomes and adverse events were prospectively recorded. during the preclinical phase, 15 POEM procedures were performed on live pigs. Severe adverse events (AE) were less frequent in group B than in group A (12 % vs 57 %, p = 0.07). After nine cases, a plateau of adverse events was reached. During the clinical phase, eleven POEM procedures were performed in patients under expert supervision. Technical and clinical (Eckardt score ≤ 3) success were 100 % and 91 %, respectively (follow-up 3-21 months). In two cases, intervention of an experienced endoscopist...Continue Reading

References

Jul 8, 2014·Gastrointestinal Endoscopy·Ming-Yan CaiQuan-Lin Li
Dec 31, 2015·Endoscopy International Open·Oscar Víctor Hernández MondragónJuan Manuel Blancas Valencia
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Sep 13, 2016·Endoscopy·Emmanuel AkintoyeChristopher C Thompson
Jun 16, 2017·Annals of Translational Medicine·Hiroki SatoShuji Terai
Jul 21, 2017·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Pablo Miranda GarcíaCecilio Santander Vaquero
Oct 11, 2017·Gastrointestinal Endoscopy·Zaheer NabiMohan Ramchandani
Jul 20, 2018·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Haruhiro InoueHisao Tajiri
Sep 1, 2018·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·G ZaninottoD E Low

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