Implementation of a Pooled Surveillance Testing Program for Asymptomatic SARS-CoV-2 Infections on a College Campus - Duke University, Durham, North Carolina, August 2-October 11, 2020

MMWR. Morbidity and Mortality Weekly Report
Thomas N DennyC. R. Wolfe

Abstract

On university campuses and in similar congregate environments, surveillance testing of asymptomatic persons is a critical strategy (1,2) for preventing transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). All students at Duke University, a private research university in Durham, North Carolina, signed the Duke Compact (3), agreeing to observe mandatory masking, social distancing, and participation in entry and surveillance testing. The university implemented a five-to-one pooled testing program for SARS-CoV-2 using a quantitative, in-house, laboratory-developed, real-time reverse transcription-polymerase chain reaction (RT-PCR) test (4,5). Pooling of specimens to enable large-scale testing while minimizing use of reagents was pioneered during the human immunodeficiency virus pandemic (6). A similar methodology was adapted for Duke University's asymptomatic testing program. The baseline SARS-CoV-2 testing plan was to distribute tests geospatially and temporally across on- and off-campus student populations. By September 20, 2020, asymptomatic testing was scaled up to testing targets, which include testing for residential undergraduates twice weekly, off-campus undergraduates one to two times per ...Continue Reading

References

Apr 19, 2020·American Journal of Clinical Pathology·Baha AbdalhamidPeter C Iwen
Jun 4, 2020·Annals of Internal Medicine·Daniel P Oran, Eric J Topol

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Citations

Feb 12, 2021·MMWR. Morbidity and Mortality Weekly Report·Lisa C BarriosMargaret J Gutilla
Jan 9, 2021·MMWR. Morbidity and Mortality Weekly Report·Christine AtherstoneUNKNOWN COVID-19 Collegiate Athlete Testing Group
Dec 11, 2020·MMWR. Morbidity and Mortality Weekly Report·Margaret A HoneinUNKNOWN CDC COVID-19 Response Team
Mar 5, 2021·PLoS Computational Biology·Vincent BraultJean-François Rupprecht
Mar 31, 2021·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Sarah FreemanCharlene A Wong
Apr 17, 2021·Population Health Management·Jason Beiriger, David B Nash
May 28, 2021·MMWR. Morbidity and Mortality Weekly Report·William A LanierAdam L Hersh
Jul 1, 2021·Academic Pathology·Balaji BalasubramaniSrikar Chamala
Jun 28, 2021·Diagnostic Microbiology and Infectious Disease·Evangeline Ann DanielLuke Elizabeth Hanna
Jul 25, 2021·International Journal of Environmental Research and Public Health·Austin T HertelSteven A Mauro
Sep 3, 2021·MMWR. Morbidity and Mortality Weekly Report·Kayleigh J NerhoodDarlene Bhavnani
Sep 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Ryan Seamus McGeeAlicia Y Zhou
Oct 3, 2021·BMJ : British Medical Journal·Nicholas J MathesonPatrick H Maxwell
Nov 11, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Naghib BogereIrene Andia-Biraro

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