Implementation of a practical and effective pilot intervention against transmission of Taenia solium by pigs in the Banke district of Nepal

PLoS Neglected Tropical Diseases
Ishab PoudelMarshall W Lightowlers

Abstract

Taenia solium is a zoonotic cestode parasite which causes human neurocysticercosis. Pigs transmit the parasite by acting as the intermediate host. An intervention was implemented to control transmission of T. solium by pigs in Dalit communities of Banke District, Nepal. Every 3 months, pigs were vaccinated with the TSOL18 recombinant vaccine (Cysvax, IIL, India)) and, at the same time, given an oral treatment with 30mg/kg oxfendazole (Paranthic 10% MCI, Morocco). The prevalence of porcine cysticercosis was determined in both an intervention area as well as a similar no intervention control area, among randomly selected, slaughter-age pigs. Post mortem assessments were undertaken both at the start and at the end of the intervention. Participants conducting the post mortem assessments were blinded as to the source of the animals being assessed. At the start of the intervention the prevalence of porcine cysticercosis was 23.6% and 34.5% in the control and intervention areas, respectively. Following the intervention, the prevalence of cysticercosis in pigs from the control area was 16.7% (no significant change), whereas no infection was detected after complete slicing of all muscle tissue and brain in animals from the intervention ...Continue Reading

References

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Jul 26, 2017·Acta Tropica·Keshav SahMarshall W Lightowlers

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Citations

Jul 10, 2019·Frontiers in Veterinary Science·Lian F ThomasJonathan Rushton
Jul 17, 2020·Frontiers in Cellular and Infection Microbiology·Valeria A SanderMarina Clemente
May 29, 2020·Clinical Microbiology Reviews·Hector H GarciaRobert H Gilman
Jul 15, 2020·Parasitology·Marianna Nascimento ManhaniJulia Maria Costa-Cruz
Sep 29, 2020·Expert Review of Proteomics·Naina Arora, Amit Prasad
Oct 2, 2019·Acta Tropica·Meritxell DonadeuMarshall W Lightowlers
Dec 16, 2020·Research in Veterinary Science·Fela MendlovicAna Flisser
Mar 22, 2021·Infectious Diseases of Poverty·Zachary NsadhaMarshall W Lightowlers
Dec 21, 2021·Pathogens and Global Health·Zhe WangSandi K Lam

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Methods Mentioned

BETA
PCR
dissection

Software Mentioned

Excel
SAS
Genstat

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