Implementation of an analytical model for leakage neutron equivalent dose in a proton radiotherapy planning system

Cancers
John EleyChristoph Bert

Abstract

Equivalent dose from neutrons produced during proton radiotherapy increases the predicted risk of radiogenic late effects. However, out-of-field neutron dose is not taken into account by commercial proton radiotherapy treatment planning systems. The purpose of this study was to demonstrate the feasibility of implementing an analytical model to calculate leakage neutron equivalent dose in a treatment planning system. Passive scattering proton treatment plans were created for a water phantom and for a patient. For both the phantom and patient, the neutron equivalent doses were small but non-negligible and extended far beyond the therapeutic field. The time required for neutron equivalent dose calculation was 1.6 times longer than that required for proton dose calculation, with a total calculation time of less than 1 h on one processor for both treatment plans. Our results demonstrate that it is feasible to predict neutron equivalent dose distributions using an analytical dose algorithm for individual patients with irregular surfaces and internal tissue heterogeneities. Eventually, personalized estimates of neutron equivalent dose to organs far from the treatment field may guide clinicians to create treatment plans that reduce the...Continue Reading

References

Jan 30, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S AgosteoG Tosi
Dec 1, 2000·Physics in Medicine and Biology·M KrämerU Weber
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Uwe SchneiderJürgen Besserer
Aug 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Graça M DoresLois B Travis
Aug 4, 2005·Physics in Medicine and Biology·Jerimy C Polf, Wayne D Newhauser
Sep 9, 2005·Physics in Medicine and Biology·Hongyu JiangHarald Paganetti
Dec 31, 2005·Radiation Protection Dosimetry·J C PolfU Titt
Apr 11, 2006·Radiation Protection Dosimetry·J D FontenotU Titt
Jul 5, 2007·Radiation Oncology·Christoph Bert, Eike Rietzel
Jul 20, 2007·Physics in Medicine and Biology·Yuanshui ZhengRadhe Mohan
Jan 17, 2009·Physics in Medicine and Biology·Angélica Pérez-AndújarPaul M Deluca
Mar 24, 2009·Physics in Medicine and Biology·Wayne D NewhauserShiao Woo
May 12, 2009·International Journal of Radiation Oncology, Biology, Physics·Jonas D FontenotWayne D Newhauser
Feb 24, 2010·Medical Physics·Ben ClasieAnatoly Rosenfeld
Apr 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm A SmithGregory H Reaman
Jul 17, 2010·Journal of the National Cancer Institute·Debra L FriedmanJoseph P Neglia
Sep 8, 2010·The New England Journal of Medicine·James O Armitage
Mar 10, 2009·AIP Conference Proceedings·Wayne D NewhauserRadhe Mohan
Nov 16, 2010·Physics in Medicine and Biology·Rui ZhangWayne D Newhauser
Nov 26, 2010·Physics in Medicine and Biology·V Anferov
May 20, 2011·Nature Reviews. Cancer·Wayne D Newhauser, Marco Durante
Aug 26, 2014·Computers in Biology and Medicine·Wayne NewhauserRui Zhang

❮ Previous
Next ❯

Citations

Feb 24, 2016·Frontiers in Oncology·Wayne D NewhauserChoonsik Lee
Nov 28, 2017·Radiation Protection Dosimetry·W D NewhauserW Donahue
Sep 12, 2019·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Yeon Soo YeomChoonsik Lee
Feb 25, 2021·Zeitschrift für medizinische Physik·Franz S EnglbrechtKatia Parodi

❮ Previous
Next ❯

Methods Mentioned

BETA
irradiate

Software Mentioned

TRiP
MCNPX

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.