Implementation of an intensive risk-stratified treatment protocol for children and adolescents with acute lymphoblastic leukemia in Lebanon

American Journal of Hematology
Samar MuwakkitMiguel R Abboud

Abstract

With modern risk-adapted therapy, over 80% of children with acute lymphoblastic leukemia (ALL) in high-income countries (HICs) are cured. In countries with limited resources, however, therapy results for pediatric ALL are still not encouraging. We describe our experience in treating children with ALL using a risk-adapted protocol at a tertiary referral center in Lebanon. From May 2002 to August 2009, 111 consecutive patients 1-21 years of age with newly diagnosed ALL received the CCCL ALL protocol which was based on the St. Jude Children's Research Hospital Total XV Study. The median age at diagnosis was 5 years 5 months. The male to female ratio was 1.5. Forty-six patients received the intermediate-/high-risk arm and 65 received the low-risk arm. Only one patient (0.9%) died during induction therapy. Relapse occurred in 8 (7.2%) patients. Eight (7.2%) patients died, 4 of whom were in remission. The median follow-up of the patients was 38 months. The 5-year overall survival and event-free survival were and 88.5% (95% CI: 77.1-94.4) and 78.7% (95% CI: 69.8-88.4), respectively. Our results are comparable to those in HICs in spite of the limited resources and the relatively low socioeconomic status of the Lebanese population. Chil...Continue Reading

References

Mar 27, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S AdvaniI Magrath
May 24, 2003·Medical and Pediatric Oncology·Ibrahim A DabbousLama Bahlawan
Jan 6, 2004·International Journal of Hematology·Ching-Hon Pui, Raul C Ribeiro
May 27, 2004·JAMA : the Journal of the American Medical Association·Scott C HowardFrancisco Pedrosa
Jul 15, 2004·Blood·Ching-Hon PuiUNKNOWN Total Therapy Study XIIIB at St Jude Children's Research Hospital
Jul 31, 2004·Journal of Pediatric Hematology/oncology·Hany HusseinNahla El-Sharkawy
Jul 20, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I MagrathV Raina
Jan 13, 2006·The New England Journal of Medicine·Ching-Hon Pui, William E Evans
Jan 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maurizio AricòValentino Conter
Aug 9, 2008·Pediatric Blood & Cancer·Ashish BajelMammen Chandy
Dec 23, 2008·Seminars in Hematology·Martin Stanulla, Martin Schrappe
May 1, 2009·Pediatric Blood & Cancer·K P KulkarniD Bansal
Jun 16, 2009·Pediatric Blood & Cancer·Yin LiuCi Pan
Jun 26, 2009·The New England Journal of Medicine·Ching-Hon PuiMary V Relling
Mar 2, 2011·Pediatric Blood & Cancer·Hadeel HalalshehFaris Madanat
Apr 9, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Ghada El-Hajj FuleihanM Abboud

❮ Previous
Next ❯

Citations

Aug 7, 2021·Leukemia & Lymphoma·Salma Abbas Al-HadadAnna Maria Testi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.