Engineered synthetic biological devices have been designed to perform a variety of functions from sensing molecules and bioremediation to energy production and biomedicine. Notwithstanding, a major limitation of in vivo circuit implementation is the constraint associated to the use of standard methodologies for circuit design. Thus, future success of these devices depends on obtaining circuits with scalable complexity and reusable parts. Here we show how to build complex computational devices using multicellular consortia and space as key computational elements. This spatial modular design grants scalability since its general architecture is independent of the circuit's complexity, minimizes wiring requirements and allows component reusability with minimal genetic engineering. The potential use of this approach is demonstrated by implementation of complex logical functions with up to six inputs, thus demonstrating the scalability and flexibility of this method. The potential implications of our results are outlined.
Data from: Implementation of complex biological logic circuits using spatially distributed multicellular consortia
Rewiring cells: synthetic biology as a tool to interrogate the organizational principles of living systems
Collaborative learning about e-health for mental health professionals and service users in a structured anonymous online short course: pilot study
Rapid and cost-effective fabrication of selectively permeable calcium-alginate microfluidic device using "modified" embedded template method
In-Silico Analysis and Implementation of a Multicellular Feedback Control Strategy in a Synthetic Bacterial Consortium
New approaches in bioprocess-control: Consortium guidance by synthetic cell-cell communication based on fungal pheromones
Advances in biomaterial engineering have permitted the development of sophisticated drug-releasing materials with a biomimetic 3D support that allow a better control of the microenvironment of transplanted cells. Here is the latest research.