Implementation of Contraction to Electrophysiological Ventricular Myocyte Models, and Their Quantitative Characterization via Post-Extrasystolic Potentiation

PloS One
Yanyan Claire JiFlavio H Fenton

Abstract

Heart failure (HF) affects over 5 million Americans and is characterized by impairment of cellular cardiac contractile function resulting in reduced ejection fraction in patients. Electrical stimulation such as cardiac resynchronization therapy (CRT) and cardiac contractility modulation (CCM) have shown some success in treating patients with HF. Computer simulations have the potential to help improve such therapy (e.g. suggest optimal lead placement) as well as provide insight into the underlying mechanisms which could be beneficial. However, these myocyte models require a quantitatively accurate excitation-contraction coupling such that the electrical and contraction predictions are correct. While currently there are close to a hundred models describing the detailed electrophysiology of cardiac cells, the majority of cell models do not include the equations to reproduce contractile force or they have been added ad hoc. Here we present a systematic methodology to couple first generation contraction models into electrophysiological models via intracellular calcium and then compare the resulting model predictions to experimental data. This is done by using a post-extrasystolic pacing protocol, which captures essential dynamics of...Continue Reading

References

May 1, 1996·Journal of Molecular and Cellular Cardiology·J A Negroni, E C Lascano
Jun 20, 1998·Circulation Research·L Priebe, D J Beuckelmann
Jan 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jeffrey J FoxRobert F Gilmour
Jan 24, 2002·Nature·Donald M Bers
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Satoshi MohriDaniel Burkhoff
Jul 25, 2003·The Japanese Journal of Physiology·Satoshi MatsuokaAkinori Noma
Sep 4, 2003·Circulation·Julie B Shea, Michael O Sweeney
Sep 4, 2004·Biophysical Journal·Vivek IyerRaimond L Winslow
Sep 7, 2004·Biophysical Journal·Thomas R ShannonDonald M Bers
May 18, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Daniel Burkhoff, Shlomo A Ben-Haim
Mar 28, 2006·American Journal of Physiology. Heart and Circulatory Physiology·K H W J ten Tusscher, A V Panfilov
Apr 13, 2006·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Gentaro IribeDenis Noble
Feb 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Leonid M Livshitz, Yoram Rudy
Oct 9, 2007·Progress in Biophysics and Molecular Biology·Martin FinkWayne R Giles
May 23, 2008·Journal of Theoretical Biology·Alfonso Bueno-OrovioFlavio H Fenton
Feb 17, 2009·Experimental Physiology·S A NiedererN P Smith
Aug 1, 2009·IEEE Transactions on Bio-medical Engineering·Raz MiriOlaf Dössel
Oct 20, 2009·Journal of Molecular and Cellular Cardiology·Eleonora GrandiDonald M Bers
Dec 31, 2009·The International Journal of Cardiovascular Imaging·Haisam Ismail, Amgad N Makaryus
Oct 19, 2010·Cardiovascular Research·Steven A NiedererNicolas P Smith
Jun 28, 2011·Progress in Biophysics and Molecular Biology·Jonathan CooperDenis Noble
Jan 4, 2013·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Feb 27, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Giovanni MoraniLuigi Padeletti
Feb 11, 2015·International Journal of Cardiology·Jürgen KuschykMartin Borggrefe

❮ Previous
Next ❯

Citations

Jun 27, 2017·Progress in Biophysics and Molecular Biology·Melanie A Zile, Natalia A Trayanova
Aug 25, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Melanie A Zile, Natalia A Trayanova
Jul 28, 2020·Progress in Biophysics and Molecular Biology·Francesca MargaraBlanca Rodriguez

❮ Previous
Next ❯

Software Mentioned

PESPC
CellML
PYCML
NL96
MATLAB

Related Concepts

Related Papers

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Bin NingChen Qin
Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Berthold StegemannTamas Szili-Török
© 2021 Meta ULC. All rights reserved