Implementation of dose superimposition to introduce multiple doses for a mathematical absorption model (transit compartment model).

Journal of Pharmacokinetics and Pharmacodynamics
Jun ShenAndrew Vick

Abstract

A mathematical absorption model (e.g. transit compartment model) is useful to describe complex absorption process. However, in such a model, an assumption has to be made to introduce multiple doses that a prior dose has been absorbed nearly completely when the next dose is administered. This is because the drug input cannot be determined from drug depot compartment through integration of the differential equation system and has to be analytically calculated. We propose a method of dose superimposition to introduce multiple doses; thereby eliminating the assumption. The code for implementing the dose superimposition in WinNonlin and NONMEM was provided. For implementation in NONMEM, we discussed a special case (SC) and a general case (GC). In a SC, dose superimposition was implemented solely using NM-TRAN abbreviated code and the maximum number of the doses that can be administered for any subject must be pre-defined. In a GC, a user-supplied function (FUNCA) in FORTRAN code was defined to perform dose superimposition to remove the restriction that the maximum number of doses must be pre-defined.

References

Jul 4, 2001·Clinical Pharmacokinetics·J DebordP Marquet
Mar 18, 2003·Journal of Clinical Pharmacology·Honghui Zhou
Jul 19, 2005·Computer Methods and Programs in Biomedicine·Lars LindbomNiclas Jonsson
Jul 27, 2007·Journal of Pharmacokinetics and Pharmacodynamics·Radojka M SavicMats O Karlsson
Mar 25, 2008·Journal of Clinical Pharmacology·Jian WangDavid Z D'Argenio
Nov 26, 2010·Journal of Pharmacokinetics and Pharmacodynamics·Wojciech Krzyzanski

❮ Previous
Next ❯

Citations

Aug 22, 2014·Journal of Pharmacokinetics and Pharmacodynamics·Gilbert KochJohannes Schropp
Apr 3, 2014·Journal of Clinical Pharmacy and Therapeutics·D ZhouN Al-Huniti
Apr 15, 2014·Journal of Clinical Pharmacology·Paweł WiczlingKathleen A Neville
Sep 10, 2014·Antimicrobial Agents and Chemotherapy·Michael J DoltonAndrew J McLachlan
Mar 16, 2017·Antimicrobial Agents and Chemotherapy·Bronner P GonçalvesRob Ter Heine
Jan 26, 2018·Journal of Pharmacokinetics and Pharmacodynamics·Shuhua HuNathan Teuscher
Jan 24, 2019·British Journal of Clinical Pharmacology·Jim H HughesDavid J R Foster
Oct 12, 2020·Journal of Pharmacokinetics and Pharmacodynamics·F Hof, L J Bridge
Jun 22, 2021·Clinical Pharmacology and Therapeutics·Jose FrancisUNKNOWN A5093, A5283, A5338 study teams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Michael WeissSrisagul Sungthongjeen
© 2021 Meta ULC. All rights reserved