Implementation of droplet-membrane-droplet liquid-phase microextraction under stagnant conditions for lab-on-a-chip applications

Analytica Chimica Acta
Tiina SikanenTapio Kotiaho

Abstract

In the current work, droplet-membrane-droplet liquid-phase microextraction (LPME) under totally stagnant conditions was presented for the first time. Subsequently, implementation of this concept on a microchip was demonstrated as a miniaturized, on-line sample preparation method. The performance level of the lab-on-a-chip system with integrated microextraction, capillary electrophoresis (CE) and laser-induced fluorescence (LIF) detection in a single miniaturized device was preliminarily investigated and characterized. Extractions under stagnant conditions were performed from 3.5 to 15 microL sample droplets, through a supported liquid membrane (SLM) sustained in the pores of a small piece of a flat polypropylene membrane, and into 3.5-15 microL of acceptor droplet. The basic model analytes pethidine, nortriptyline, methadone, haloperidol, and loperamide were extracted from alkaline sample droplets (pH 12), through 1-octanol as SLM, and into acidified acceptor droplets (pH 2) with recoveries ranging between 13 and 66% after 5 min of operation. For the acidic model analytes Bodipy FL C(5) and Oregon Green 488, the pH conditions were reversed, utilizing an acidic sample droplet and an alkaline acceptor droplet, and 1-octanol as SL...Continue Reading

Citations

Sep 12, 2012·Analytical and Bioanalytical Chemistry·Isabelle KohlerSerge Rudaz
Jan 13, 2016·Analytica Chimica Acta·Juan Antonio Ocaña-GonzálezMaría Ramos-Payán
Mar 8, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Abdulmumin A NuhuBahruddin Saad
Sep 11, 2012·Advanced Materials·Ville JokinenTiina Sikanen
Oct 15, 2011·Analytica Chimica Acta·Archana Jain, Krishna K Verma
Jun 21, 2015·Analytica Chimica Acta·Eduardo Carasek, Josias Merib
Sep 4, 2016·Analytica Chimica Acta·Yousef Abdossalami AslMaryam Rezazadeh
Aug 10, 2017·Electrophoresis·María Ramos-PayánMiguel Ángel Bello-López
Apr 23, 2021·Analytical and Bioanalytical Chemistry·Elia SantigosaMaría Ramos-Payán
Jan 10, 2012·Analytical Chemistry·Vladimir GubalaDavid E Williams
May 6, 2019·Analytical Chemistry·Maizatul Najwa JajuliGrégoire Herzog

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