Implementation of individualized medicine for cancer patients by multiomics-based analyses—the Project HOPE—

Biomedical Research
Ken YamaguchiMasatoshi Kusuhara

Abstract

The Project HOPE (High-tech Omics-based Patient Evaluation) for cancer medicine aims to evaluate biological characteristics of each cancer tissue as well as diathesis of each patient in around 1,000 consecutive cases per year, who receive operations at the Shizuoka Cancer Center. Cancer tissues are investigated by whole-exome sequencing for 18,835 genes, focusing on 12,776 in-house cancer hotspots from 483 cancer-associated genes. To confirm cancer-specific genetic changes, we analyzed blood cells to collate with data of cancer tissues, and we reevaluate cancer tissues by comprehensive cancer panel for 409 genes. In order to investigate diathesis of the patients, we evaluate 43,015 hotspots associated with non-cancerous diseases. In terms of gene expression profiling, we analyze cancer-specific alterations for 29,833 genes using tumor and adjacent normal tissues. If and when necessary, we investigate tumor and normal tissues by proteomics and metabolomics. The model experiments using glioblastoma cell lines demonstrated that the method is appropriate for clinical application. The Project HOPE makes it possible to implement individualized medicine and to practice preventive and presymptomatic medicine for cancer patients. Furthe...Continue Reading

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Citations

Mar 19, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kenichi NakamuraMasanori Terashima
Sep 24, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Keiichi FujiyaKen Yamaguchi
Dec 23, 2016·Biomedical Research·Yuji ShimodaKen Yamaguchi
Mar 23, 2017·The Journal of Toxicological Sciences·Sumiko OhnamiKen Yamaguchi
Aug 23, 2016·Biomedical Research·Ken YamaguchiMasatoshi Kusuhara
Mar 5, 2017·Molecular and Cellular Biochemistry·Shumpei OhnamiKen Yamaguchi
Jul 25, 2020·Medicine·Yoshiyuki IidaTetsuro Onitsuka
Feb 26, 2016·Biomedical Research·Kenichi UrakamiKen Yamaguchi
Aug 18, 2017·Omics : a Journal of Integrative Biology·Theodora KatsilaDimitrios Kardamakis
Oct 14, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yoshimi KiyozumiKen Yamaguchi
Sep 4, 2021·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kenichiro FurukawaKen Yamaguchi

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