Implementation of spot scanning dose optimization and dose calculation for helium ions in Hyperion

Medical Physics
Hermann FuchsDietmar Georg

Abstract

Helium ions ((4)He) may supplement current particle beam therapy strategies as they possess advantages in physical dose distribution over protons. To assess potential clinical advantages, a dose calculation module accounting for relative biological effectiveness (RBE) was developed and integrated into the treatment planning system Hyperion. Current knowledge on RBE of (4)He together with linear energy transfer considerations motivated an empirical depth-dependent "zonal" RBE model. In the plateau region, a RBE of 1.0 was assumed, followed by an increasing RBE up to 2.8 at the Bragg-peak region, which was then kept constant over the fragmentation tail. To account for a variable proton RBE, the same model concept was also applied to protons with a maximum RBE of 1.6. Both RBE models were added to a previously developed pencil beam algorithm for physical dose calculation and included into the treatment planning system Hyperion. The implementation was validated against Monte Carlo simulations within a water phantom using γ-index evaluation. The potential benefits of (4)He based treatment plans were explored in a preliminary treatment planning comparison (against protons) for four treatment sites, i.e., a prostate, a base-of-skull, ...Continue Reading

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Citations

Mar 14, 2018·Medical Physics·Fatima Padilla-CabalHermann Fuchs
Apr 14, 2017·Physics in Medicine and Biology·T TessonnierK Parodi
Jan 30, 2019·Physics in Medicine and Biology·Wioletta S KozłowskaDietmar Georg
May 21, 2016·Physics in Medicine and Biology·A MairaniT Haberer
Jul 19, 2017·Physics in Medicine and Biology·Andreas F ReschDietmar Georg

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