Implementation of the European multicentre database of healthy controls for [(123)I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes

European Journal of Nuclear Medicine and Molecular Imaging
Nathalie L AlbertChristian la Fougère

Abstract

Even though [(123)I]FP-CIT SPECT provides high accuracy in detecting nigrostriatal cell loss in neurodegenerative parkinsonian syndromes (PS), some patients with an inconclusive diagnosis remain. We investigated whether the diagnostic accuracy in patients with clinically uncertain PS with previously inconclusive findings can be improved by the use of iterative reconstruction algorithms and an improved semiquantitative evaluation which additionally implemented a correction algorithm for patient age and gamma camera dependency (EARL-BRASS; Hermes Medical Solutions, Sweden). We identified 101 patients with inconclusive findings who underwent an [(123)I]FP-CIT SPECT between 2003 and 2010 as part of the diagnostic process of suspected PS at the University of Munich, and re-evaluated these scans using iterative reconstruction algorithms and the new corrected EARL-BRASS. Clinical follow-up was obtained in 62 out of the 101 patients and constituted the gold standard for the re-evaluation to assess the possible improvement in diagnostic accuracy. Clinical follow-up confirmed the diagnosis of PS in 11 of the 62 patients. In patients in whom both visual and semiquantitative analysis showed concordant findings (48 patients), a high negativ...Continue Reading

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Citations

Jun 4, 2016·Acta Neurologica Scandinavica·L RamaniE J Newman
Jun 22, 2016·Journal of Neural Transmission·Elina MäkinenValtteri Kaasinen
May 26, 2017·Current Opinion in Neurology·Daniela FrosiniRoberto Ceravolo
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May 6, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jan BooijPhillip H Kuo

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