Implemented myeloma management with whole-body low-dose CT scan: a real life experience

Leukemia & Lymphoma
Silvia MangiacavalliA Corso

Abstract

A total of 318 consecutive myeloma patients underwent whole-body low-dose CT scan (WBLDCT) at baseline and during follow-up as a radiological assessment of lytic lesions in place of skeletal X-ray survey. After WBLDCT baseline assessment, 60% had bone involvement. The presence of lytic lesions represented the only met CRAB (hyperCalcaemia, Renal insufficiency, Anaemia, Bone lesions) criteria in 29% of patients. Patients presenting with extramedullary masses were 10%. Radiological progression was documented in 9% of the population with available follow-up. Additional pathological incidental findings were detected in 28 patients (14.5%), most located in the chest region (68%). In conclusion, our real-life data shows that WBLDCT scan represents a reliable imaging tool for decision-making process for multiple myeloma management in different disease phases, providing significant additional information on the presence of soft tissues plasmacytomas detection as well as the presence of pathological incidental findings.

References

Jun 2, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Terpos, M-A Dimopoulos
Jun 17, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Brian G M Durie
Feb 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ronald WalkerEdgardo J Angtuaco
Feb 15, 2013·Cancer Investigation·Kelechi PrincewillMichael Mulligan
Jul 10, 2014·The British Journal of Radiology·A SurovD Schramm
Oct 9, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew J PiankoSuzanne Lentzsch
Dec 3, 2014·The Lancet Oncology·S Vincent RajkumarJesus F San Miguel
Oct 4, 2015·Haematologica·Evangelos TerposUNKNOWN European Myeloma Network

❮ Previous
Next ❯

Citations

Dec 7, 2019·Hematology·Elisabet E Manasanch
Sep 2, 2017·Current Osteoporosis Reports·Cristina PanaroniNoopur S Raje
Jan 19, 2021·Dose-response : a Publication of International Hormesis Society·Dario BaldiMarco Salvatore

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.