PMID: 8947703Jan 1, 1996Paper

Implementing the Bayesian paradigm: reporting research results over the World-Wide Web

Proceedings : a Conference of the American Medical Informatics Association
H P Lehmann, M R Wachter

Abstract

For decades, statisticians, philosophers, medical investigators and others interested in data analysis have argued that the Bayesian paradigm is the proper approach for reporting the results of scientific analyses for use by clients and readers. To date, the methods have been too complicated for non-statisticians to use. In this paper we argue that the World-Wide Web provides the perfect environment to put the Bayesian paradigm into practice: the likelihood function of the data is parsimoniously represented on the server side, the reader uses the client to represent her prior belief, and a downloaded program (a Java applet) performs the combination. In our approach, a different applet can be used for each likelihood function, prior belief can be assessed graphically, and calculation results can be reported in a variety of ways. We present a prototype implementation, BayesApplet, for two-arm clinical trials with normally-distributed outcomes, a prominent model for clinical trials. The primary implication of this work is that publishing medical research results on the Web can take a form beyond or different from that currently used on paper, and can have a profound impact on the publication and use of research results.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

M.D. Computing : Computers in Medical Practice
H P Lehmann, B Nguyen
Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation
Peng-Cheng WangXiao-Juan Zhai
Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation
Wei-jing XueJian Meng
Medical Informatics = Médecine Et Informatique
H Sippel, C Ohmann
© 2021 Meta ULC. All rights reserved