Implementing TMB measurement in clinical practice: considerations on assay requirements.

ESMO Open
Reinhard BüttnerFrédérique Penault-Llorca

Abstract

Clinical evidence demonstrates that treatment with immune checkpoint inhibitor immunotherapy agents can have considerable benefit across multiple tumours. However, there is a need for the development of predictive biomarkers that identify patients who are most likely to respond to immunotherapy. Comprehensive characterisation of tumours using genomic, transcriptomic, and proteomic approaches continues to lead the way in advancing precision medicine. Genetic correlates of response to therapy have been known for some time, but recent clinical evidence has strengthened the significance of high tumour mutational burden (TMB) as a biomarker of response and hence a rational target for immunotherapy. Concordantly, immune checkpoint inhibitors have changed clinical practice for lung cancer and melanoma, which are tumour types with some of the highest mutational burdens. TMB is an implementable approach for molecular biology and/or pathology laboratories that provides a quantitative measure of the total number of mutations in tumour tissue of patients and can be assessed by whole genome, whole exome, or large targeted gene panel sequencing of biopsied material. Currently, TMB assessment is not standardised across research and clinical s...Continue Reading

References

Oct 8, 1999·Immunity·E Gilboa
Dec 6, 2002·The American Journal of Pathology·Mythily SrinivasanScott Jewell
Nov 6, 2009·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·W E Grizzle
Jan 13, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark E RobsonUNKNOWN American Society of Clinical Oncology
May 21, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Martin Kircher, Janet Kelso
Dec 1, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Bruno BuecherAstrid Lièvre
Dec 22, 2012·The EMBO Journal·Bianca HeemskerkTon N M Schumacher
Mar 14, 2013·Oncoimmunology·Stephen R Mattarollo, Mark J Smyth
Jul 3, 2013·The Journal of Molecular Diagnostics : JMD·Rajesh R SinghRajyalakshmi Luthra
Aug 16, 2013·Nature·Ludmil B AlexandrovMichael R Stratton
Jan 10, 2014·Oncoimmunology·Rory J GeyerPramod K Srivastava
Jan 18, 2014·Nature Reviews. Genetics·David SimsChris P Ponting
Jan 25, 2014·Nature Reviews. Cancer·Pierre G CoulieThierry Boon
Feb 25, 2014·Methods : a Companion to Methods in Enzymology·William J Howat, Beverley A Wilson
Jul 12, 2014·Journal of Clinical Pathology·Ian A CreeUNKNOWN Royal College of Pathologists
Nov 20, 2014·The New England Journal of Medicine·Alexandra SnyderTimothy A Chan
Apr 4, 2015·Science·Ton N Schumacher, Robert D Schreiber
Jun 2, 2015·The New England Journal of Medicine·Dung T LeLuis A Diaz
Sep 2, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark E RobsonNoralane M Lindor
Sep 12, 2015·The Journal of Molecular Diagnostics : JMD·Lotte N J MoensJohan Botling
Sep 12, 2015·Science·Eliezer M Van AllenLevi A Garraway
Dec 3, 2015·Cancer Cytopathology·Sinchita Roy-ChowdhuriGregg Staerkel
Mar 24, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric BouffetUri Tabori
May 3, 2016·International Journal of Molecular Sciences·Ping QiuDiane Levitan
May 22, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J M Kim, D S Chen
Jul 9, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roman M ChabanonSophie Postel-Vinay
Aug 27, 2016·Annals of Translational Medicine·Michalis LiontosMeletios-Athanasios Dimopoulos
Nov 3, 2016·Cancer Immunology Research·Douglas B JohnsonChristine M Lovly
Nov 12, 2016·Cancer Gene Therapy·N B Jamieson, A V Maker

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Citations

Nov 7, 2019·Expert Review of Molecular Diagnostics·Jennifer CrowAndrew K Godwin
Jan 15, 2020·Der Pathologe·Britta Janina Wagner, Reinhard Buettner
Apr 14, 2020·JCO Clinical Cancer Informatics·Sehyun OhMarkus Riester
Apr 22, 2020·American Society of Clinical Oncology Educational Book·Galina G LagosNaiyer A Rizvi
May 13, 2020·British Journal of Clinical Pharmacology·Geoffrey Alan WatsonAnna Spreafico
Oct 2, 2020·Genetics and Molecular Biology·Reginaldo Cruz Alves RosaVictor Evangelista de Faria Ferraz
Mar 12, 2020·Oncogene·David J PinatoLorenza Rimassa
Apr 8, 2020·Frontiers in Cell and Developmental Biology·Aleksandra FilipovicJoseph Bolen
Jul 11, 2020·Scientific Reports·Carina HeydtSabine Merkelbach-Bruse
Jun 7, 2020·Nature Communications·Vito W RebeccaMeenhard Herlyn
Sep 10, 2019·Therapeutic Advances in Medical Oncology·Jia Li LowRoss A Soo
Sep 13, 2019·Expert Review of Respiratory Medicine·Antonio Rossi
Oct 11, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P GarridoF López-Ríos
May 10, 2020·British Journal of Clinical Pharmacology·Vishal NavaniAndre Van Der Westhuizen
Oct 13, 2020·Expert Review of Anticancer Therapy·Svenja Wagener-Ryczek, Reinhard Buettner
Oct 6, 2020·Scandinavian Journal of Immunology·Andreas HallqvistSukanya Raghavan
Oct 25, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Ching Ngar WongDavid J Pinato
Jun 14, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew D GalskyPadmanee Sharma
Dec 31, 2020·Cancer Cytopathology·Francesco PepeUmberto Malapelle
Dec 4, 2020·Critical Reviews in Oncology/hematology·Eleonora LaiMario Scartozzi
Jan 30, 2021·Future Oncology·Santosh GautamAnirban Basu
Oct 31, 2020·Cancer Cell·Denis L JardimRazelle Kurzrock
Feb 10, 2021·Cancers·Eftychia StavrakakiMartine L M Lamfers
Dec 15, 2020·Current Breast Cancer Reports·Jamaal L James, Justin M Balko
Dec 4, 2020·Journal for Immunotherapy of Cancer·Siwen Hu-LieskovanHolden T Maecker
Nov 18, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John H StricklerMustafa Khasraw
Mar 25, 2020·The Journal of Molecular Diagnostics : JMD·Leonie I KroezeMarjolijn J L Ligtenberg

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Methods Mentioned

BETA
exome sequencing
biopsy
biopsies
GTPase

Software Mentioned

IMPACT
FoundationOne CDx
MSK
FoundationOne

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