Implication of 2-18fluor-2-deoxyglucose positron emission tomography in the follow-up of Hürthle cell thyroid cancer

Thyroid : Official Journal of the American Thyroid Association
Michail PlotkinHans-Wilhelm Müller-Gärtner

Abstract

The aim of this retrospective study was to investigate the value of positron emission tomography (PET) with 2-18fluor-2-deoxy-glucose (FDG) in the follow-up of Hürthle cell thyroid cancer (HTC), a rare variant of thyroid malignancies. FDG-PET studies were performed in 17 patients with HTC. In subgroup A (n = 13) PET was initiated because of an elevated thyroglobulin (Tg) level whereas in subgroup B (n = 4) the study was performed to evaluate suspect findings of morphologic imaging while Tg remained undetectable. Pathologically increased FDG uptake was found in all patients of subgroup A. In 10 studies, PET results were proven as true-positive either by surgery or by morphologic imaging. One study was false-positive. Final evaluation was not possible in two cases. In subgroup B, PET was true-negative in three and false-positive in one patient. For the detection of recurrent HTC by means of FDG-PET a meta-analysis including data of a multicenter study revealed an overall sensitivity of 92%, a specificity of 80%, a positive predictive value of 92%, and a negative predictive value of 80% while the accuracy was 89%. This study supports the efficiency of FDG-PET in the follow-up of HTC.

References

Dec 1, 1984·Mayo Clinic Proceedings·R G WatsonW F Taylor
Oct 1, 1995·Surgery·A AzadianS L Asa
Jan 1, 1994·Experimental and Clinical Endocrinology·A SchmidtD Schams
Mar 1, 1996·European Journal of Nuclear Medicine·F GrünwaldH J Biersack
May 1, 1996·Cancer Treatment Reviews·C L Harmer, V R McCready
Mar 1, 1996·Endocrinology and Metabolism Clinics of North America·R J Galloway, R C Smallridge
Jan 1, 1996·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·D SimonH D Röher
Jan 19, 2000·European Journal of Nuclear Medicine·F GrünwaldH J Biersack

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Citations

Jan 24, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Sophie LeboulleuxPaul W Ladenson
Jan 22, 2004·Clinical Nuclear Medicine·Daniel R ScangaDominique Delbeke
Jun 6, 2008·Nuclear Medicine Communications·Marc D ZuijdwijkWim J G Oyen
Oct 13, 2009·Journal of Endocrinological Investigation·M NajiA Al-Nahhas
May 23, 2014·AJR. American Journal of Roentgenology·Charles MarcusRathan M Subramaniam
Sep 27, 2003·The British Journal of Radiology·N KhanK Endo
May 1, 2009·Expert Opinion on Medical Diagnostics·Muammer UrhanAbass Alavi
Oct 1, 2012·PET Clinics·Muammer UrhanAbass Alavi
Mar 6, 2016·Revista española de medicina nuclear e imagen molecular·M A Muros de FuentesE Navarro González
Dec 2, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Richard J Robbins, Steven M Larson
Dec 2, 2008·Otolaryngologic Clinics of North America·Nafi Aygun
Jul 1, 2007·PET Clinics·Muammer UrhanCristina Nanni
Jun 24, 2008·Molecular and Cellular Endocrinology·Raffaele CiampiRossella Elisei
Feb 24, 2011·ANZ Journal of Surgery·Ivan Ho ShonPeter Campbell
Jun 18, 2004·Seminars in Nuclear Medicine·Heiko Schöder, Henry W D Yeung
Oct 19, 2004·Radiologic Clinics of North America·Hongming ZhuangAbass Alavi
Sep 25, 2007·Arquivos brasileiros de endocrinologia e metabologia·Nathan C Hall, Richard T Kloos
Jan 1, 2011·Case Reports in Hepatology·J A StephensonA R Dennison
Oct 16, 2007·Arquivos brasileiros de endocrinologia e metabologia·Valesca M KubaMário Vaisman
Mar 23, 2019·Reviews in Endocrine & Metabolic Disorders·Arnoldo PiccardoLuca Giovanella
Apr 1, 2004·Journal of Endocrinological Investigation·M SalvatoriL Troncone
Sep 5, 2020·Journal of Nuclear Medicine Technology·Twyla B Bartel ChairShari Moreau

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