PMID: 7546999Aug 1, 1995Paper

Implication of anterior septal malalignment in isolated ventricular septal defect

British Heart Journal
M H WuH C Lue

Abstract

The aim was to define the long term prognosis of isolated ventricular septal defect (VSD) with anteriorly malaligned outlet septum. Cohort study. University hospital, tertiary medical care centre. Between July 1986 and June 1993, 63 patients were studied with an isolated VSD and anteriorly malaligned outlet septum (59 perimembranous; 4 muscular outlet). The diagnosis of septal malalignment, aneurysmal transformation, right ventricular obstruction, subaortic ridge, and aortic valve prolapse was based on echocardiographic criteria, then confirmed by angiography in 33 patients and by surgery in 28. An actuarial curve for each event was obtained by Kaplan-Meier non-parametric analysis and the significance was examined by log-rank test. Aneurysmal transformation decreased the size of the VSD in 52% of the patients, but was also associated with the appearance of subaortic ridge (p < 0.05). Progressive obstruction in the right ventricle was observed in 51%, more often in those without aneurysmal transformation (p < 0.05). Aortic valve prolapse was quite common whether or not aneurysmal transformation occurred (33% and 23%, respectively). This was attributed to the location of the VSD and the anterior malalignment of the outlet septum....Continue Reading

References

Jan 1, 1977·The American Journal of Cardiology·J M SigmannH E Sloan
May 1, 1989·The American Journal of Cardiology·F HelmckeB Soto
Mar 1, 1988·British Heart Journal·E J BakerJ R Zuberbuhler
Jul 1, 1970·The American Journal of Cardiology·R Van PraaghM H Paul
Sep 1, 1993·The American Journal of Cardiology·M H WuH C Lue

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Citations

Mar 6, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Toshiharu MiyakeTsukasa Takemura
Mar 31, 2005·The Annals of Thoracic Surgery·Shuenn-Nan ChiuMei-Hwan Wu
Nov 11, 2020·Journal of the American Heart Association·Shi-Joon YooAndreea Dragulescu

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