PMID: 9169301May 1, 1997Paper

Implication of beta 1- and beta 2-adrenergic receptors in the antinociceptive effect of tricyclic antidepressants

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
J A MicóJ S Serrano

Abstract

Tricyclic antidepressants have been shown to be useful for the treatment of pain of varying etiology. Monoaminergic systems seem to be implicated in this phenomenon. In this study, the influence of the selective beta 1- (CGP 20712A) and beta 2- (ICI 118551) adrenergic blockers on the antinociceptive effect of desipramine and nortriptyline was studied in mice using physical and chemical nociceptive tests that implicate different levels of sensory-motor integration in the central nervous system (CNS). An activity test was performed to detect "false positive" or "false negative" results. Results obtained show that both CGP 20712A and ICI 118551 are able to antagonize the antinociceptive effect of these antidepressants in physical tests (hot-plate and tail-flick). However, in chemical tests (acetic acid and formalin), the analgesic effect of the antidepressants used was only antagonized by CGP 20712A. These results suggest that the analgesic effect of desipramine and nortriptyline is mediated by beta-adrenoceptors. The beta-adrenoceptor involved depends on the type of nociceptive stimulus: beta 1 and beta 2 are both implicated when the stimulus is physical, but only beta 1 is involved when the stimulus is chemical.

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Citations

Sep 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M O Rojas-CorralesJ A Micó
Jul 4, 2012·The Journal of Clinical Investigation·Hyangin KimJianren Mao
Nov 8, 2006·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Donatella MarazzitiBernardo Dell'Osso
Jan 16, 2008·CNS Drugs·Gary McCleane
Sep 8, 2011·International Journal of Ayurveda Research·Manju Bhaskar, A G Jagtap
Feb 17, 2015·Veterinary Anaesthesia and Analgesia·Christopher NorkusButch KuKanich
Jun 10, 2006·Trends in Pharmacological Sciences·Juan A MicóAlain Eschalier
Oct 3, 2006·Pharmacology & Therapeutics·Sharon Rosenzweig-LipsonLee E Schechter
Jun 20, 2003·Journal of Endodontics·Kenneth M HargreavesWalter R Bowles
Mar 26, 2003·Journal of Dental Research·W R BowlesK M Hargreaves
Nov 17, 2009·British Journal of Pharmacology·Nada Choucair-JaafarMichel Barrot
Jan 17, 2020·Frontiers in Neuroscience·Lidia BravoJuan Antonio Micó
Jul 23, 2020·Frontiers in Neuroscience·Ananda Staats PiresAlexandra Latini
Mar 19, 2011·Journal of Clinical Pharmacology·Pinky DharmshaktuBhupinder Singh Kalra
Aug 30, 2008·Bioorganic & Medicinal Chemistry·Lorena dos SantosRicardo José Nunes

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