Implication of Candida parapsilosis FKS1 and FKS2 mutations in reduced echinocandin susceptibility

Antimicrobial Agents and Chemotherapy
M Martí-CarrizosaP Coll

Abstract

We evaluated FKS1 and FKS2 mutations in Candida parapsilosis bloodstream isolates and correlated them with the echinocandin MIC values determined by guidelines in CLSI document M27-A3 and the YeastOne panel. All mutations detected were outside hot spot (HS) regions. The F1386S mutation detected in an isolate that was resistant by the YeastOne panel but not by the M27-A3 guidelines might be implicated in echinocandin resistance. Further studies are needed to confirm the implication of the F1386S mutation and to elucidate the capability of the M27-A3 guidelines to detect echinocandin resistance.

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Citations

Jan 24, 2016·The Journal of Antimicrobial Chemotherapy·Anna Kołaczkowska, Marcin Kołaczkowski
Oct 5, 2017·Future Microbiology·Tânia P SalciTerezinha Ie Svidzinski
Jun 20, 2016·Mycopathologia·Francieli ChassotSydney Hartz Alves
Mar 1, 2019·Clinical Microbiology Reviews·Renáta TóthAttila Gácser
Jun 13, 2020·Frontiers in Cellular and Infection Microbiology·Louise A Walker, Carol A Munro
Feb 28, 2019·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Guillermo QuindósElena Eraso
Jul 24, 2021·Revista iberoamericana de micología·Inmaculada Quiles-Melero, Julio García-Rodríguez

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