PMID: 7539207Jan 1, 1995Paper

Implication of cytokines in the aggravation of malnutrition and hypercatabolism in elderly patients with severe pressure sores

Age and Ageing
M BonnefoyL Rys

Abstract

The objectives of this work were to study the production of the cytokines Interleukin 1 (IL-1), Interleukin 6 (IL-6), and tumour necrosis factor (TNF) in elderly patients with severe pressure sores and to assess their potential contribution to the aggravation of malnutrition. Nineteen bedridden patients with stage III or IV pressure sores, 12 bedridden patients free from pressure sores, but at risk of them, and 12 control patients without risk of pressure sores were studied. Nutritional status was evaluated using anthropometry, serum albumin, prealbumin, retinol-binding protein analyses, and delayed hypersensitivity skin tests. Acute-phase proteins (APP), cortisol, and cytokines blood levels together with cytokine production were measured. Nutritional status was poor in patients with sores and their APP, and IL-6 blood levels were significantly increased; IL-1 and TNF serum concentrations were not elevated in these patients. A significant difference in cortisol levels was observed between patients with stage III and IV sores. A local cytokine origin (especially IL-6, and also IL-1) was demonstrated. Thus cytokines, mainly IL-6, produced by tissue cells in damaged areas together with cortisol may aggravate malnutrition and hyper...Continue Reading

Citations

Feb 27, 2003·Aging Clinical and Experimental Research·Michael GengenbacherWalter O Seiler
Dec 4, 2003·Cancer Letters·Tohru NakagoeShimeru Kamihira
Mar 10, 2001·Nutrition·I Bourdel-Marchasson, V Rondeau
Jan 25, 2006·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Nur TurhanMeral Bayramoğlu
Oct 6, 2001·Drugs & Aging·D R Thomas
Jun 15, 2011·Journal of Tissue Viability·Denis AnthonyMa'en Aljezawi
Oct 30, 2007·Archives of Physical Medicine and Rehabilitation·Andrew L DaviesGregory A Dekaban
Jan 1, 1997·Archives of Physical Medicine and Rehabilitation·J L SegalS R Brunnemann
Sep 27, 2005·Journal of the American Dietetic Association·Bobbi Langkamp-HenkenKelli A Herrlinger-Garcia
Jul 27, 2002·Critical Care Clinics·Thomas H Kalb, Scott Lorin
Jul 15, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J C DesportP Ritz
Aug 2, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Shinji IizakaYoshiki Miyachi
Nov 18, 2000·Journal of the American Geriatrics Society·D B ReubenT B Harris
Oct 14, 2008·Nutrition·Lorenzo M DoniniCarlo Cannella
Sep 13, 2000·Revista do Hospital das Clínicas·D F CunhaV P Teixeira
Mar 1, 1997·JPEN. Journal of Parenteral and Enteral Nutrition·M Y RadyN J Starr
Feb 1, 2011·Journal of Wound Care·F J Stephenson
Nov 3, 2007·Advances in Skin & Wound Care·Katherine R JonesAmber Lenihan
Jul 20, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stefany D PrimeauxGregory M Holmes
Oct 5, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A Raynaud-SimonS Darquy
Aug 24, 2002·Journal of Wound Care·J Hart
Feb 6, 2020·Revista do Colégio Brasileiro de Cirurgiões·Filipe Carlos CaronJorge Rufino Ribas Timi
Aug 12, 1999·Zeitschrift für Gerontologie und Geriatrie·W O Seiler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved