Implication of fraction of exhaled nitric oxide and blood eosinophil count in severe asthma

Allergology International : Official Journal of the Japanese Society of Allergology
Tomoyuki SomaMakoto Nagata

Abstract

Severe asthma is a complex disease with heterogeneous features and involves type 2 airway inflammation, including eosinophil accumulation. Surrogate biomarkers, fraction of exhaled nitric oxide (FeNO) and blood eosinophil count (b-EOS), may predict eosinophilic airway inflammation. Here we investigated clinical characteristics of severe asthma phenotype using a combined analysis of FeNO and b-EOS. This retrospective study examined clinical data of patients with severe asthma (N = 107; median age, 64 years) treated at Saitama Medical University Hospital from 2009 to 2016. Thresholds of FeNO and b-EOS for sputum eosinophil ratio ≥2% were determined using receiver operating characteristic curve (ROC) analysis. Clinical characteristics were analyzed after classifying patients into four subgroups according to these thresholds. Of 39 induced sputum samples examined, ROC area under the curve for predicting sputum eosinophilia was 82.0% (p = 0.001) for b-EOS and 77.0% (p = 0.006) for FeNO at optimal cut-off values of ≥300/μL and ≥25 ppb, respectively. The number of sensitized allergens was higher in the high FeNO/low b-EOS and high FeNO/high b-EOS subgroups (p < 0.05). The prevalence of chronic sinusitis was higher in the low FeNO/high...Continue Reading

Citations

Oct 28, 2019·Current Opinion in Allergy and Clinical Immunology·Ida MogensenAndrei Malinovschi
Jan 18, 2020·The European Respiratory Journal·Andrew Menzies-GowChristopher E Brightling
May 8, 2020·Biomarkers in Medicine·Salvatore FuschilloMauro Maniscalco
May 16, 2020·Asia Pacific Allergy·Tomoyuki SomaMakoto Nagata
Nov 21, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Meng ChenEugene Choo
Mar 20, 2021·Journal of Asthma and Allergy·Luis Pérez de LlanoIrene Martin Robles
Jun 18, 2021·Pulmonology·Pedro Carreiro-MartinsCláudia Loureiro

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