Implication of human drug transporters to toxicokinetics and toxicity of pesticides

Pest Management Science
Nelly GuénicheOlivier Fardel

Abstract

Human membrane drug transporters are recognized as major actors of pharmacokinetics. Pesticides also interact with human drug transporters, which may have consequences for pesticide toxicokinetics and toxicity. The present review summarizes key-findings about this topic. In vitro assays have demonstrated that some pesticides, belonging to various chemical classes, modulate drug transporter activity, regulate transporter expression and/or are substrates, thus bringing the proof of concept for pesticide-transporter relationships. The expected low human concentration of pesticides in response to environmental exposure constitutes a key-parameter to be kept in mind for judging the in vivo relevance of such pesticide-transporter interactions and their consequences for human health. Existing data about interactions of pesticides with drug transporters remain, however, rather sparse; more extensive and systematic characterization of pesticide-transporter relationships, through the use of high throughput in vitro assays and/or in silico methods, is, therefore, required. In addition, consideration of transporter polymorphisms, pesticide mixture effects and physiological and pathological factors governing drug transporter expression may ...Continue Reading

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Citations

Dec 9, 2020·Pest Management Science·Stephen O Duke
Nov 23, 2020·FEBS Letters·Sascha C T Nicklisch, Amro Hamdoun
Apr 3, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K DarneyL S Lautz
Mar 19, 2021·Critical Reviews in Biotechnology·Pankaj BhattShaohua Chen
Jun 12, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Sascha C T NicklischAmro Hamdoun

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