Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study

Scientific Reports
Kyung Mook ChoiSeon Mee Kim

Abstract

Although liver enzymes, such as γ-glutamyltransferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), have recently been suggested as risk factors for cardiovascular diseases (CVD), impact on mortality after myocardial infarction (MI) or ischemic stroke (IS) was not previously examined. Using a population-based, nationwide cohort database, we explored the implication of GGT and aminotransferases on the development of CVD and all-cause mortality during a median 9.1 years of follow-up. Among 16,624,006 Korean adults, both GGT and aminotransferases exhibited a positive relationship with MI, IS, and mortality in a multivariate adjusted model. ALT and AST showed U-shaped associations with mortality, whereas GGT showed a positive linear relationship with mortality. The risk of 1-year mortality after MI or IS was significantly higher in the highest quartile of GGT compared to the lowest quartile (HR, 1.46; 95% CI, 1.40-1.52). The implication of GGT on MI, IS, and mortality persisted regardless of traditional cardiovascular risk parameters. This study demonstrated the unique pattern of association of ALT, AST, and GGT with the development of CVD and all-cause mortality in the Korean population. In particula...Continue Reading

References

Sep 21, 2001·Critical Reviews in Clinical Laboratory Sciences·J B Whitfield
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Saverio StrangesMaurizio Trevisan
Jun 29, 2005·Circulation·Peter Libby, Pierre Theroux
Jun 29, 2005·Diabetes Care·Monica NannipieriUNKNOWN Mexico City diabetes study
Sep 28, 2005·Circulation·Elfriede RuttmannUNKNOWN Vorarlberg Health Monitoring and Promotion Program Study Group
Jan 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Emilio OrtegaJoy C Bunt
Nov 8, 2006·Journal of the American Geriatrics Society·Eran ElinavJochanan Stessman
Nov 11, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Douglas S LeeRamachandran S Vasan
Dec 23, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Scott M Grundy
Jul 12, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Alexander M StrasakUNKNOWN Vorarlberg Health Monitoring and Promotion Program Study Group
Aug 30, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Duk-Hee LeeDavid R Jacobs
Jul 25, 2009·Current Treatment Options in Cardiovascular Medicine·Sweta Tandra, Raj Vuppalanchi
Dec 22, 2009·Preventive Cardiology·Jennifer E MasonJohn E Van Kirk
Jul 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nazim GhouriNaveed Sattar
Sep 8, 2010·Journal of Hepatology·Federico Salamone, Elisabetta Bugianesi
Mar 3, 2015·Diabetes & Metabolism Journal·Hye Jin Yoo, Kyung Mook Choi
Apr 11, 2015·Archives of Medical Science : AMS·Maciej BanachDimitri P Mikhailidis
Jun 4, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Chang-Mo OhIn-Hwan Oh
Aug 1, 2015·Journal of Clinical Lipidology·Alper SonmezManfredi Rizzo
Sep 16, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Xiao-Wei ZhangZhen-Yu Tang
Dec 15, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Aynur Unalp-Arida, Constance E Ruhl
Jan 30, 2016·International Journal of Epidemiology·Juneyoung LeeKeeWhan Kim
Feb 16, 2016·Journal of Atherosclerosis and Thrombosis·Yuanying LiUNKNOWN EPOCH-JAPAN Research Group
Sep 2, 2017·Journal of the American College of Cardiology·Robert S RosensonPaul D Thompson

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Citations

Oct 21, 2018·Scientific Reports·Qinhao LinGuoqing Di
Apr 17, 2019·International Journal of Environmental Research and Public Health·Hyun-Jin KimKyoung-Bok Min
May 10, 2020·Archives of Iranian Medicine·Shadi KolahdoozanHosein Poustchi
Jan 14, 2021·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Aksam A YassinFarid Saad
Sep 13, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Gjin NdrepepaAdnan Kastrati
Mar 17, 2021·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Xiao ZhangXiaohui Xu
May 20, 2021·Journal of Clinical and Translational Hepatology·Yi HanYongning Xin
Jul 9, 2021·BioMed Research International·Maryam KohsariEbrahim Shakiba
Jul 13, 2021·Journal of Cardiovascular Pharmacology and Therapeutics·Xiao ZhangXiaohui Xu
Sep 4, 2021·Digestive Diseases and Sciences·Ho Soo ChunSeung Up Kim
Sep 16, 2021·Hepatology International·Takahisa MoriYuhei Tanno
Oct 10, 2021·Internal and Emergency Medicine·Diego Martínez-UrbistondoUNKNOWN RIETE Investigators
Nov 24, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Joonhyoung KimSei Yeul Oh
Dec 4, 2021·American Journal of Human Genetics·Yue WuSriram Sankararaman
Dec 12, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Muhammad NaeemTill Ittermann

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