Implication of microRNAs in the pathogenesis of MDS.

Current Pharmaceutical Design
Jing FangDaniel T Starczynowski

Abstract

MicroRNAs (miRNAs) are significant regulators of human hematopoietic stem cells (HSC), and their deregulation contributes to hematological malignancies. Myelodysplastic syndromes (MDS) represent a spectrum of hematological disorders characterized by dysfunctional HSC, ineffective blood cell production, progressive marrow failure, and an increased risk of developing acute myeloid leukemia (AML). Although miRNAs have been primarily studied in AML, only recently have similar studies been performed on MDS. In this review, we describe the normal function and expression of miRNAs in human HSC, and describe mounting evidence that deregulation of miRNAs contributes to the pathogenesis of MDS.

Citations

May 24, 2018·Cardiovascular & Hematological Disorders Drug Targets·Ota Fuchs
Jan 4, 2018·Blood Advances·Chi-Yuan YaoHwei-Fang Tien
Feb 15, 2018·Frontiers in Oncology·Stephanie Rebecca SetijonoSu Jung Song
Nov 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tahereh ZeinaliBehzad Baradaran
Aug 9, 2021·The American Journal of Pathology·Dahai WangAnnette S Kim

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