PMID: 7581489Jan 1, 1995Paper

Implication of nitric oxide synthase in carcinogenesis: analysis of the human inducible nitric oxide synthase gene

Pharmacogenetics
H EsumiA Weisz

Abstract

Nitric oxide (NO) is a newly identified, multifunctional biological mediator. However, it also has deleterious effects on biological materials. For instance, nucleic acids, proteins, and some prosthetic groups of enzymes can be modified by NO or its reaction products with other reactive oxygen species. Endogenous nitrosamine formation through the reaction of NO or its oxidized products with amines might be involved in carcinogenesis. These deleterious effects of NO are often associated with inflammatory processes both in experimental animals and human. We analyzed the molecular mechanism of control of expression of the inducible nitric oxide synthase (NOS) gene in mouse cells by cloning its putative promoter region. This promoter responded to various cytokines and endotoxin similarly to the endogenous NOS gene in mouse cells. No appreciable induction of NOS was observed in human peripheral blood cells, but induction was detected in a human glioblastoma cell line A-172. Therefore, the human inducible NOS cDNA was cloned from A-172 cells and its cDNA-deduced amino acid sequence found to have about 80% similarity to those of both mouse and rat inducible NOSs. The effects of various cytokines on the induction of the gene were somew...Continue Reading

Citations

Aug 26, 1998·Clinical and Experimental Immunology·K D KrönckeV Kolb-Bachofen
Feb 17, 2005·Brain Research·Diego GarbossaAlessandro Vercelli
Oct 6, 2000·Nitric Oxide : Biology and Chemistry·M Onoda, H Inano
Jul 15, 2016·Antioxidants & Redox Signaling·Anh N TranAnita B Hjelmeland
Oct 17, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M Onoda, H Inano
Aug 13, 2003·Journal of Gastroenterology and Hepatology·Masayuki TatemichiHiroyasu Esumi
Oct 9, 1996·Biochimica Et Biophysica Acta·S Tamir, S R Tannenbaum

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