Implication of oxidative stress and its correlation with activity of matrix metalloproteinases in patients with Takayasu's arteritis disease

International Journal of Cardiology
Nitin MahajanSanjay Jain

Abstract

Oxidative stress and activation of matrix metalloproteinases (MMPs) together have been widely implicated in various inflammatory vascular disorders. As Takayasu's arteritis (TA) is an inflammatory disorder characterized by destruction of elastic fibers, we hypothesized that oxidative stress and MMPs might play an important role in pathophysiology of the disease. 40 patients with clinically defined TA and equal number of normal, healthy, controls were enrolled in the study. Subjects with TA were further divided into clinically active disease or in remission phase of the disease. Augmented levels of 8-isoPGF(2α) (238.9±125.7 vs 79.5±29.1 ng/ml), nitrite (NO(2)(-)) (14.9±15.6 vs 3.3±1.7 μM) were observed in TA patients as compared to the controls (p<0.01). Further, 8-iso-PGF(2α) (272.2±117.3 vs 105.9±43.5 ng/ml) and NO(2)(-) (17.9±16.1 vs 3.1±2.5 μM) levels were higher in subjects with active disease vs those in remission (p<0.05). Zymography pattern revealed two bands in the range of 85-92 kDa (MMP-9) and 65-72 kDa (MMP-2). Total gelatinolytic activity was found to be significantly higher in subjects with TA as compared to the controls (p<0.05). Gelatinolytic activity was moderately low in controls and subjects in remission as co...Continue Reading

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Citations

May 31, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sampath SanthoshSanjay Jain
Jun 29, 2010·International Journal of Cardiology·Nitin MahajanSanjay Jain
Dec 12, 2012·International Reviews of Immunology·Dan WenChang-Sheng Ma
Oct 3, 2014·BioMed Research International·Gang WuVeena Dhawan
Aug 8, 2014·Oxidative Medicine and Cellular Longevity·María Elena SotoIsrael Pérez-Torres
Apr 7, 2018·International Journal of Rheumatic Diseases·Ying SunLindi Jiang
Feb 1, 2011·Journal of Neurochemistry·Sandra L SilvaDora Brites
Jun 1, 2021·Frontiers in Cardiovascular Medicine·Yaxin ZhouZhenbiao Wu

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