Abstract
Resveratrol (RES), a natural plant polyphenol, is an effective inducer of cell cycle arrest and apoptosis in a variety of carcinoma cell types. In addition, RES has been reported to inhibit tumorigenesis in several animal models suggesting that it functions as a chemopreventive and anti-tumor agent in vivo. The chemopreventive and chemotherapeutic properties associated with resveratrol offer promise for the design of new chemotherapeutic agents. However, the mechanisms by which RES mediates its effects are not yet fully understood. In this study, we showed that RES caused cell cycle arrest and proliferation inhibition via induction of unfolded protein response (UPR) in human leukemia K562 cell line. Treatment of K562 cells with RES induced a number of signature UPR markers, including transcriptional induction of GRP78 and CHOP, phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha), ER stress-specific XBP-1 splicing, suggesting the induction of UPR by RES. RES inhibited proliferation of K562 in a concentration-dependent manner. Flow cytometric analyses revealed that K562 cells were arrested in G1 phase upon RES treatment. Salubrinal, an eIF2alpha inhibitor, or overexpression of dominant negative mutants of PERK or e...Continue Reading
References
Jan 10, 1997·Science·M JangJ M Pezzuto
May 27, 1999·Genes & Development·R J Kaufman
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·J W BrewerJ A Diehl
May 31, 2001·The Journal of Cell Biology·I NovoaD Ron
Jul 27, 2001·Carcinogenesis·J GusmanG Atassi
Mar 22, 2002·The Journal of Biological Chemistry·Kun MaRonald C Wek
Aug 2, 2002·Carcinogenesis·Hélène Ferry-DumazetM Djavad Mossalayi
Mar 20, 2003·Molecular Pharmacology·Ursula G B HaiderVerena M Dirsch
Mar 29, 2003·Biochemical Pharmacology·Yu-Chih LiangJen-Kun Lin
Jan 30, 2004·Experimental & Molecular Medicine·Ji Hyun KangWon Jung Lee
Sep 15, 2004·Journal of Chemical Neuroanatomy·Yanjun Ma, Linda M Hendershot
Dec 18, 2004·Mutation Research·Martin Schröder, Randal J Kaufman
Jan 27, 2005·Cancer Letters·Susanne U Mertens-Talcott, Susan S Percival
Feb 12, 2005·Science·Michael BoyceJunying Yuan
Jul 27, 2005·The Journal of Nutritional Biochemistry·Paola Signorelli, Riccardo Ghidoni
Nov 1, 2005·Developmental Cell·Mohan ViswanathanLeonard Guarente
Nov 18, 2006·Cell Proliferation·U StervboC Bonnesen
Feb 20, 2007·Toxicology and Applied Pharmacology·Mohammad AtharArianna L Kim
Jun 15, 2007·Nature Reviews. Molecular Cell Biology·David Ron, Peter Walter
Aug 30, 2007·Cell Cycle·Valeria CucciollaFulvio Della Ragione
Sep 18, 2007·Biochemical Pharmacology·Valentina CecchinatoPaola Comi
Feb 5, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexandre PuissantPatrick Auberger
Apr 24, 2008·Cancer Science·Prabir K ChakrabortySanghamitra Raha
Sep 2, 2008·Biochemical Pharmacology·Oxana Komina, Józefa Wesierska-Gadek
May 12, 2009·Biochemical Pharmacology·Seung Hun JeongYoung Hyun Yoo
Citations
Feb 1, 2013·Biopreservation and Biobanking·William L CorwinRobert G Van Buskirk
Jun 22, 2010·Journal of Neurotrauma·Richard H SingletonC Edward Dixon
Mar 23, 2011·BMC Cancer·Xiao-Fang NiuHua-Qin Wang
Feb 25, 2011·Journal of Hematology & Oncology·Xuemei LiZihai Li
Feb 2, 2013·PloS One·Ly Quoc TrungShinji Nakao
Apr 14, 2016·Blood Cells, Molecules & Diseases·Andria TheodorouMarina Kleanthous
Apr 27, 2010·Ageing Research Reviews·Antero Salminen, Kai Kaarniranta
Oct 23, 2014·Journal of Cancer Prevention·Raj Kumar YadavHan Jung Chae
Jan 13, 2011·The Plant Journal : for Cell and Molecular Biology·Yuhya WakasaFumio Takaiwa
Jul 19, 2011·British Journal of Haematology·Jee-Yeong JeongGary J Vanasse
Nov 9, 2011·Journal of Cellular Biochemistry·Wei YuWei Wang
Jul 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ammad Ahmad FarooqiHsueh-Wei Chang
Feb 11, 2014·Cryobiology·William L CorwinRobert G Van Buskirk
Feb 2, 2013·Cell Cycle·Javier A MenendezAntonio Segura-Carretero
Dec 3, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zhao ZhaoXiangjun Sun
Dec 2, 2014·PloS One·Cristina RojasMiquel Mulero
Jan 22, 2013·Toxicologic Pathology·Marc A LafleurJeffrey W Lawrence
Oct 24, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Damiano RossiGianni Sacchetti
Feb 5, 2019·Oncoimmunology·Mattias CarlstenRichard W Childs
Sep 11, 2014·Critical Reviews in Food Science and Nutrition·Attilio GiacosaMariangela Rondanelli
Jun 3, 2021·Cancer Science·Yuanhua CaiShaoyuan Wang
May 11, 2019·Experimental Cell Research·Daniel W ColeAndrew M Fribley