Implication of Xenobiotic Metabolizing Enzyme gene (CYP2E1, CYP2C19, CYP2D6, mEH and NAT2) polymorphisms in breast carcinoma.

BMC Cancer
Achraf KhedhaierLotfi Chouchane

Abstract

Xenobiotic Metabolizing Enzymes (XMEs) contribute to the detoxification of numerous cancer therapy-induced products. This study investigated the susceptibility and prognostic implications of the CYP2E1, CYP2C19, CYP2D6, mEH and NAT2 gene polymorphisms in breast carcinoma patients. The authors used polymerase chain reaction and restriction enzyme digestion to characterize the variation of the CYP2E1, CYP2C19, CYP2D6, mEH and NAT2 gene in a total of 560 unrelated subjects (246 controls and 314 patients). The mEH (C/C) mutant and the NAT2 slow acetylator genotypes were significantly associated with breast carcinoma risk (p = 0.02; p = 0.01, respectively). For NAT2 the association was more pronounced among postmenopausal patients (p = 0.006). A significant association was found between CYP2D6 (G/G) wild type and breast carcinoma risk only in postmenopausal patients (p = 0.04). Association studies of genetic markers with the rates of breast carcinoma specific overall survival (OVS) and the disease-free survival (DFS) revealed among all breast carcinoma patients no association to DFS but significant differences in OVS only with the mEH gene polymorphisms (p = 0.02). In addition, the mEH wild genotype showed a significant association ...Continue Reading

References

Jan 19, 1996·Cancer Letters·M G LadonaJ Benítez
Aug 1, 1997·Pharmacogenetics·J L Ruas, M C Lechner
Feb 25, 1999·The Australian and New Zealand Journal of Surgery·I C BennettB T Teh
Mar 16, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S J LondonA K Daly
Jan 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P FritzU M Zanger
Dec 26, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F BrayD M Parkin
Jan 26, 2002·Cancer Letters·S W BaxterI G Campbell
Jan 30, 2002·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael Thun
Apr 16, 2002·Journal of Medical Genetics·M M de JongE G E de Vries
Dec 11, 2002·Journal of Cancer Research and Clinical Oncology·Sandra CostaCarlos Lopes
Mar 15, 2003·Nature Reviews. Cancer·Steven A Narod
May 29, 2003·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·P M FerreiraC Lopes
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wonshik HanDong-Young Noh
Jun 5, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Maria Gabriella ScordoEdoardo Spina
Jun 8, 2004·Current Drug Metabolism·Jose A G Agundez
Jul 1, 2004·Cancer Detection and Prevention·Anthony J AlbergDouglas A Bell
Aug 24, 2004·Oncogene·Donald M Parkin
Feb 23, 2005·Current Medicinal Chemistry·Jean-Marie Dupret, Fernando Rodrigues-Lima
Mar 24, 2005·Journal of Cellular and Molecular Medicine·R G Dumitrescu, I Cotarla
Jun 6, 2007·Clinical Endocrinology·Manuel C LemosFernando J Regateiro

❮ Previous
Next ❯

Citations

Feb 25, 2010·Breast Cancer Research and Treatment·Jian ZhangXi-Chun Hu
Nov 9, 2010·Journal of Toxicology and Environmental Health. Part a·Gary P Carlson
Apr 2, 2011·Genetic Testing and Molecular Biomarkers·Lakshmi BalajiSolomon F D Paul
May 1, 2013·International Journal of Biological Sciences·Timothy A McCaffreySidney W Fu
Feb 4, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Ana Fernández-SantanderFernando Bandrés Moya
May 21, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wen-Feng GongLe-Qun Li
Sep 25, 2014·Archives of Toxicology·Ahmed A El-Sherbeni, Ayman O S El-Kadi
Jan 23, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tengfei Wang, Hany E Marei
Jul 10, 2009·Cancer Detection and Prevention·Slah OuerhaniAmel Benammar ElGaaied
Apr 25, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Zhe ZhangChui-Ze Kong
Sep 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Li-Ping ZhouHong Shang
Mar 26, 2013·Cancer Epidemiology·Jesse D TroyJennifer R Grandis
Mar 19, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Hassan R Dhaini, Loulou Kobeissi
Mar 30, 2017·Annals of Human Biology·Hiba Chelouti, Malika Khelil
Mar 2, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Eric Tzyy Jiann ChongPing-Chin Lee
Aug 9, 2017·BioMed Research International·Jenny RuedlingerLuis A Salazar
Nov 18, 2016·Journal of Translational Medicine·Hager MemniElham Hassen
Jun 10, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Julie LeeBørge G Nordestgaard
Apr 30, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jean E AbrahamCarlos Caldas
Feb 11, 2021·Personalized Medicine·Gholamreza FarnooshMohammad-Reza Mahmoudian-Sani
May 19, 2020·Current Cancer Drug Targets·Hadeil M E IdrisAbozer Y Elderdery

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
genotyping
acetylating
acetylator

Software Mentioned

STATISTIQUES
SEM

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.