Implications and issues related to familial pancreatic cancer: a cohort study of hospitalized patients

BMC Gastroenterology
Martina MughettiRaffaele Pezzilli

Abstract

The surveillance of subjects at risk of pancreatic cancer is restricted to clinical research; the incidence of familial pancreatic cancer needs to be better established. Thus, we aimed to evaluate the frequency of familial pancreatic cancer in a population of hospitalized patients with pancreatic cancer. A retrospective study based on the hospital charts of patients discharged with a diagnosis of pancreatic cancer. One hundred and eighty-seven patients or their relatives were called for a phone interview. There were 97 males (51.9 %) and 90 (48.1 %) females. The overall mean ± SD age was 67.3 ± 11.8 years; the age of males was similar to that of females (P = 0140). The mean size of the tumors found was 36.3 ± 17.4 mm (range of 5-110 mm); it was related to gender but was not related to the site of the tumor or the age of the patient. Regarding genetic diseases, three females (1.6 %) had familial adenomatous polyposis; three patients (1 male and two females) (1.6 %) had at least one relative with pancreatic cancer whereas only one 80-year old male patient (0.5 %) had two relatives affected by pancreatic cancer (the mother had died at the 65 years of age and the brother had died at 75 years of age). The frequency of familial pancr...Continue Reading

References

Jul 14, 1994·The New England Journal of Medicine·L GulloUNKNOWN Italian Pancreatic Cancer Study Group
Oct 1, 1995·Pancreas·L GulloUNKNOWN Italian Pancreatic Cancer Study Group
Jan 9, 2003·Gastrointestinal Endoscopy·Stephen J RulyakTeresa A Brentnall
Sep 16, 2005·Pancreas·Raffaele PezzilliLucio Gullo
Apr 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wenyi WangAlison P Klein
Oct 4, 2007·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Maxim S PetrovMikhail V Kukosh
Jul 16, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Marco Del ChiaroUNKNOWN Italian Registry for Familial Pancreatic Cancer
May 9, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Raffaele Pezzilli, Antonio Maria Morselli-Labate
Oct 11, 2012·World Journal of Gastroenterology : WJG·Raffaele PezzilliAndrea Imbrogno
Nov 9, 2012·Gut·Marcia Irene CantoUNKNOWN International Cancer of Pancreas Screening (CAPS) Consortium
May 9, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Elisabetta BuscariniUNKNOWN Cystic Pancreatic Neoplasm Study Group
Sep 19, 2014·World Journal of Gastroenterology : WJG·Marco Del ChiaroCaroline Verbeke
Oct 31, 2014·Genetics in Medicine : Official Journal of the American College of Medical Genetics·David B ZhenGloria M Petersen
Dec 3, 2014·European Journal of Internal Medicine·Agostino Di Ciaula, Piero Portincasa
Dec 6, 2014·Pancreas·Valentina RosatoCarlo La Vecchia
Apr 15, 2015·Pancreas·Shumaila N KhawjaGeorge Van Buren
Jul 28, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E MocciA Carrato

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

SPSS
PancPro

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