PMID: 9552367Jan 1, 1995Paper

Implications for cAMP-dependent protein kinase in the maintenance of the interphase state

Progress in Cell Cycle Research
A FernandezN Lamb

Abstract

The cAMP dependent protein kinase (A-kinase) is one of the first and best studied kinases in mammalian cells. There is extensive evidence that A-kinase activity acts antagonistically toward mitotic entry both in oocyte and somatic cells. Firstly, A-kinase seems to directly compromise the activation process of the cdc2 cyclin B mitotic kinase. Secondly, as shown by specific in vivo inhibition of A-kinase using microinjection of a stable form of its inhibitor peptide PKI, A-kinase modulates several key interphase cellular processes including cytoskeletal dynamics, transcription, chromatin structure and nuclear localization. We discuss the potential mechanisms involved in the down regulation of A-kinase activity at the interphase/mitosis transition.

Citations

Dec 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Brian C DuckworthJoan V Ruderman
Jan 13, 2004·Physiological Reviews·Kjetil Taskén, Einar Martin Aandahl
Apr 4, 2001·The Journal of Biological Chemistry·K A TaskénK Taskén
Feb 15, 2014·Nature Communications·Aude DupréOlivier Haccard
Jul 23, 2008·Experimental Cell Research·Pedro Rodriguez-CollazoCatharine L Smith

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