Implications for cardiac surgery in patients with factor XII deficiency

The Annals of Thoracic Surgery
Paul J ConaglenVictoria Atkinson

Abstract

Factor XII deficiency is associated with a prolonged activated partial thromboplastin time and activated clotting time used for monitoring during cardiopulmonary bypass. It does not predispose to an increased risk of bleeding. We present the strategy used for a case of coronary artery bypass grafting in a patient with factor XII deficiency, followed by a brief discussion of the important clinical considerations when patients with factor XII deficiency undergo cardiac surgery. Monitoring of heparin and the avoidance of anti-fibrinolytic agents are the main intraoperative issues. Postoperative care must include careful thromboembolic prophylaxis and vigilance against infection.

References

Nov 1, 1994·The Annals of Thoracic Surgery·M K Wood
Aug 1, 1993·Journal of Cardiothoracic and Vascular Anesthesia·R M MoormanM E Comunale
Apr 1, 1955·The Journal of Clinical Investigation·O D RATNOFF, J E COLOPY
Aug 30, 2008·The Journal of Clinical Investigation·Alvin H Schmaier
Dec 17, 2008·European Journal of Haematology·Joost Jair van VeenMike Makris

❮ Previous
Next ❯

Citations

Feb 15, 2013·Anesthesia and Analgesia·Alan Finley, Charles Greenberg
Jul 20, 2012·American Journal of Hematology·Oxana TcherniantchoukMarisa B Marques
Aug 22, 2017·Frontiers in Medicine·Fabrício Simão, Edward P Feener
Jun 24, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Jelena VuckovicLazar Velicki
Jun 17, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Tiina ErkinaroEeva-Riitta Savolainen
Jun 20, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Yoshikazu KimuraHidekuni Hidaka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.