Implications of a school outbreak of multidrug-resistant tuberculosis in Northern China

Epidemiology and Infection
Xiaoguang WuMengqiu Gao

Abstract

In this study, we identified a multidrug-resistant tuberculosis (MDR-TB) outbreak in a high school in northern China. The aim of this work was to describe TB transmission, drug resistance and treatment outcomes for this patient cluster. In January 2017, pulmonary TB was identified in a 17-year-old boy in northern China. Subsequently, a total of 11 TB cases were identified during 6-month follow-up of attendees of the same school. Of five students with latent TB infection (LTBI) receiving isoniazid preventive therapy (IPT), two pulmonary TB cases (40.0%) emerged in March and April, for an active case rate not significantly different from that of the non-IPT group (4/16, 25.0%, P = 0.598). All TB patients were first treated with a standardised first-line treatment regimen administered by the local TB hospital, with 11 of 12 active TB patients exhibiting poor treatment outcomes. Further data demonstrated that all nine patient isolates collected during this outbreak were MDR-TB and shared a common genotypic profile. In conclusion, our data demonstrate that diagnostic delay for the index MDR-TB case of this outbreak played a primary role in transmission of MDR-TB infection within a school setting. Importantly, IPT failed to prevent p...Continue Reading

References

Sep 1, 1996·Journal of the Air & Waste Management Association·S Miller-LeidenJ M Macher
Jan 21, 2006·American Journal of Respiratory and Critical Care Medicine·Timothy R SterlingUNKNOWN Tuberculosis Epidemiologic Studies Cosortium
Feb 5, 2009·PloS One·Ming ZhaoQian Gao
Mar 22, 2013·Journal of Clinical Microbiology·Yu PangYanlin Zhao
Sep 24, 2013·Therapeutic Advances in Respiratory Disease·Madhavi J Parekh, Neil W Schluger
Jan 24, 2014·The New England Journal of Medicine·Gavin J ChurchyardUNKNOWN Thibela TB Study Team
Apr 23, 2014·Current Opinion in Infectious Diseases·H Simon SchaafJames A Seddon
Feb 15, 2015·The Lancet Infectious Diseases·Lei GaoUNKNOWN LATENTTB-NSTM study team
Mar 12, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mai-Juan MaWu-Chun Cao
Apr 29, 2015·American Journal of Respiratory and Critical Care Medicine·Gregory J FoxDick Menzies
Nov 26, 2015·Epidemiology and Infection·C-C LaiH-H Chen
Mar 5, 2016·PLoS Medicine·Christian LienhardtMario Raviglione
Jun 9, 2016·BMC Infectious Diseases·Anke L StuurmanMarieke J van der Werf

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Citations

Sep 11, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Qi JiangQian Gao
Dec 14, 2018·International Journal of Environmental Research and Public Health·Dongxiang PanVirasakdi Chongsuvivatwong
Jun 20, 2020·American Journal of Respiratory and Critical Care Medicine·Chuan-Chin HuangMegan Murray
Aug 28, 2021·Tropical Medicine and Infectious Disease·Katherine M LaycockAndrew P Steenhoff
Oct 30, 2021·Frontiers in Public Health·Hui LiGuolong Zhang

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