Implications of AMPK in the Formation of Epithelial Tight Junctions

International Journal of Molecular Sciences
Pascal RowartFrançois Jouret

Abstract

Tight junctions (TJ) play an essential role in the epithelial barrier. By definition, TJ are located at the demarcation between the apical and baso-lateral domains of the plasma membrane in epithelial cells. TJ fulfill two major roles: (i) TJ prevent the mixing of membrane components; and (ii) TJ regulate the selective paracellular permeability. Disruption of TJ is regarded as one of the earliest hallmarks of epithelial injury, leading to the loss of cell polarity and tissue disorganization. Many factors have been identified as modulators of TJ assembly/disassembly. More specifically, in addition to its role as an energy sensor, adenosine monophosphate-activated protein kinase (AMPK) participates in TJ regulation. AMPK is a ubiquitous serine/threonine kinase composed of a catalytic α-subunit complexed with regulatory β-and γ-subunits. AMPK activation promotes the early stages of epithelial TJ assembly. AMPK phosphorylates the adherens junction protein afadin and regulates its interaction with the TJ-associated protein zonula occludens (ZO)-1, thereby facilitating ZO-1 distribution to the plasma membrane. In the present review, we detail the signaling pathways up-and down-stream of AMPK activation at the time of Ca2+-induced TJ ...Continue Reading

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Citations

Nov 12, 2019·Journal of Animal Physiology and Animal Nutrition·Liqing HuangZhaofei Xia
Oct 23, 2019·International Journal of Molecular Sciences·Séverine OlivierBenoit Viollet
Nov 7, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mahyar AghapourIrene H Heijink
Feb 15, 2019·International Journal of Molecular Sciences·Dietbert Neumann, Benoit Viollet
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nutthapoom PathomthongtaweechaiChatchai Muanprasat
Feb 10, 2021·Biochemical and Biophysical Research Communications·Harleen Kaur, Régis Moreau
Feb 17, 2021·Investigative Ophthalmology & Visual Science·Fanfei LiuLawrence J Rizzolo
Nov 25, 2020·Microbial Pathogenesis·Tianfeng MaYongxiang Tian
Aug 12, 2020·Archives of Biochemistry and Biophysics·Dorota RogackaAgnieszka Piwkowska
Apr 1, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yu-Zhi LuWan-Li Ma
Jul 1, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Preedajit WongkrasantChatchai Muanprasat

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BETA
immunoprecipitation
transgenic

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